Esophageal Collision Tumor (Large Cell Neuroendocrine Carcinoma and Papillary Carcinoma) Arising in a Barrett Esophagus

Abstract We report herein a unique case of an esophageal collision tumor composed of a papillary adenocarcinoma and a large cell neuroendocrine carcinoma arising in a Barrett esophagus. Hematoxylin-eosin and silver staining patterns, immunohistochemistry, and electron microscopy of the large cell neuroendocrine component are discussed.

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Collision tumor of the urinary bladder comprising Large cell neuroendocrine carcinoma and adenocarcinoma

Asian Journal of Oncology ◽

10.4103/asjo.asjo_14_16 ◽

2017 ◽

Vol 03 (02) ◽

pp. 144-146

Author(s):

Jatin Sundersham Gandhi ◽

Sunil Pasricha ◽

Gurudutt Gupta

Keyword(s):

Urinary Bladder ◽

Neuroendocrine Tumors ◽

Neuroendocrine Carcinoma ◽

Large Cell ◽

Collision Tumor ◽

Large Cell Neuroendocrine Carcinoma ◽

Rare Tumors

AbstractLarge cell neuroendocrine tumors of the bladder are rare tumors. Their co-association with adenocarcinoma is even rarer. We present a third undisputed case of collision tumor comprising large cell neuroendocrine carcinoma and adenocarcinoma of the urinary bladder in a 73-year-old gentleman with a revisit to its origin and histogenesis.

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Large Cell Neuroendocrine Carcinoma: Topic Review and a Unique Case of Metastasis to the Mandible

Journal of Maxillofacial and Oral Surgery ◽

10.1007/s12663-012-0362-x ◽

2012 ◽

Vol 14 (S1) ◽

pp. 120-126 ◽

Cited By ~ 2

Author(s):

Keith M. Schneider ◽

Alan Y. Martinez ◽

Marcello Guglielmi

Keyword(s):

Neuroendocrine Carcinoma ◽

Large Cell ◽

Large Cell Neuroendocrine Carcinoma ◽

Unique Case

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Gastric collision tumor of large cell neuroendocrine carcinoma and adenocarcinoma – A case report

Pathology - Research and Practice ◽

10.1016/j.prp.2009.09.003 ◽

2010 ◽

Vol 206 (6) ◽

pp. 387-390 ◽

Cited By ~ 11

Author(s):

Kyu Yun Jang ◽

Woo Sung Moon ◽

Ho Lee ◽

Chan Young Kim ◽

Ho Sung Park

Keyword(s):

Case Report ◽

Neuroendocrine Carcinoma ◽

Large Cell ◽

Collision Tumor ◽

Large Cell Neuroendocrine Carcinoma

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Collision Tumor of Endometrial Large Cell Neuroendocrine Carcinoma and Low-Grade Endometrial Stromal Sarcoma: A Case Report and Review of the Literature

International Journal of Surgical Pathology ◽

10.1177/1066896920901764 ◽

2020 ◽

Vol 28 (5) ◽

pp. 569-573

Author(s):

Glorimar Rivera ◽

Shuang Niu ◽

Hao Chen ◽

Dina Fahim ◽

Yan Peng

Keyword(s):

Neuroendocrine Carcinoma ◽

Endometrial Stromal Sarcoma ◽

Large Cell ◽

Collision Tumor ◽

Large Cell Neuroendocrine Carcinoma ◽

Low Grade ◽

Histologic Subtype ◽

Stromal Sarcoma ◽

Pathologic Features ◽

Microscopic Evaluation

Large cell neuroendocrine carcinoma (LCNEC) of the endometrium is an exceedingly rare histologic subtype of endometrial cancer (0.8%). These tumors are highly aggressive with a propensity for metastasis and have a poor prognosis. Among the 17 cases reported to date, 9 cases were pure large cell neuroendocrine tumors and 8 were collision tumors of LCNEC with endometrial carcinomas (7 endometrioid and 1 serous). In this article, we report a case of collision tumor composed of an endometrial LCNEC and a low-grade endometrial stromal sarcoma (LGESS). The patient was a 48 year-old woman who presented with a large abdominal mass for about 10 years and underwent total hysterectomy, bilateral salpingo-oophorectomy, and tumor debulking. Microscopic evaluation demonstrated an LGESS with extensive osseous metaplasia that penetrated through the myometrium and invaded into pelvic and abdominal cavity, forming a 40.0-cm mass. Cytogenetic analysis of the LGESS revealed an abnormal female karyotype (45, XX) with multiple structural abnormalities. Incidentally, small foci of LCNEC were identified within the endometrium. The LCNEC focally invaded the myometrium with involvement of the endocervix, extensive lymph-vascular space invasion, and metastases to bilateral ovaries. Subsequently, the patient was treated with cisplatin/etoposide chemotherapy and had been doing well for about a year until presenting with recurrence of LCNEC in the abdomen. She passed away a month later due to medical complications. This report reveals an extremely rare endometrial collision tumor with unusual pathologic features and clinical presentations.

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