atypical carcinoid
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2021 ◽  
Author(s):  
Harim Kim ◽  
Ho Yun Lee ◽  
Se‐Hoon Lee ◽  
In Sun Lee ◽  
Joon Young Choi ◽  
...  

2021 ◽  
pp. 201010582110507
Author(s):  
Muhammad Syafiek Mohd Razali ◽  
Muhammad Amin Ibrahim ◽  
Adli Azam Mohammad Razi ◽  
Mohammed Fauzi Abdul Rani

We present a 70-year-old gentleman with chronic cough with haemoptysis found to have left lower zone collapse on imaging. The bronchoscopy showed an endobronchial mass histologically of a non-secreting atypical carcinoid. Poor baseline lung function excluded surgical resection, and instead, he successfully underwent a bronchoscopic debulking procedure which improved his FEV1 to 84% and DLCO 83% predicted. Unfortunately, the tumour regrew, but the calculated percentage predicted postoperative for FEV1 (64%), and DLCO (65%) enabled definitive surgical resection to take place. Surgical resection remains the definite curative option for localised endobronchial atypical carcinoid tumours. Achieving this in proximal endobronchial carcinoid tumour is a challenge. We described an endoscopic tumour debulking procedure as a bridge for curative surgical resection in a patient with an inoperable proximal atypical carcinoid tumour due to poor predicted postoperative lung function. We highlighted the need to assess predicted postoperative lung function with functional and quantitative perfusion methods to aid surgical planning. Debulking the tumour by endoscopy can be used as a conduit to curative surgical resection in bronchial carcinoid tumour. The choice of calculating the percentage predicted values by either or both methods must be individualised based on tumour location and the probability of converting a lobectomy to a pneumonectomy. This precautionary approach could evaluate the postoperative lung function and morbidity and mortality risk if considering a pneumonectomy. Endoscopic debulking can be a successful bridge to a curative surgical resection aided by comprehensive preoperative lung function tests to predict postoperative lung values


2021 ◽  
Vol 8 ◽  
Author(s):  
Paola Parente ◽  
Antonio Rossi ◽  
Angelo Sparaneo ◽  
Federico Pio Fabrizio ◽  
Antonella Centonza ◽  
...  

Pulmonary carcinoids combined with a non-neuroendocrine component have rarely been described, and this histological subtype is not included as a specific entity in the current World Health Organization classification of pulmonary neoplasms. Here, we described the molecular and histological features of two rare cases of mixed lung neoplasms, composed of atypical carcinoid and adenocarcinoma. The targeted next-generation sequencing analysis covering single nucleotide variations, copy number variations, and transcript fusions in a total of 161 cancer genes of the two different tumor components shows a similar molecular profile of shared and private gene mutations. These findings suggest their monoclonal origin from a transformed stem/progenitor tumor cell, which acquires a divergent differentiation during its development and progression and accumulates novel, specific mutations.


Author(s):  
Yu-Qing Chen ◽  
Yu-Fa Li ◽  
Chan-Yuan Zhang ◽  
Shi-Ling Zhang ◽  
Zhi-Yi Lv ◽  
...  

2021 ◽  
pp. 101550
Author(s):  
Ryosuke Amemiya ◽  
Ikki Takada ◽  
Yuki Yazaki ◽  
Shotaro Ono ◽  
Keni Kou ◽  
...  

2021 ◽  
Vol 127 (5) ◽  
pp. S87
Author(s):  
S. Patrawala ◽  
T. Bingemann ◽  
S. Khurana
Keyword(s):  

2021 ◽  
Author(s):  
Cheng Shen ◽  
Lin Ma

Abstract Background: There were very few reports of atypical carcinoid in anterior mediastinum. Atypical carcinoids originating in the mediastinum belong to a neuroendocrine tumor (NET), which is also a very rare clinically aggressive mediastinal tumor. Case presentation: We herein reported a rare case of NET of mediastinal origin and a review of several cases concerning the clinical and pathological features of this disease, which is often misdiagnosed as atypical carcinoid tumor in mediastinum. The tumor was removed by mid-sternal thoracotomy with superior vena cava formation, left common carotid artery resection and artificial blood vessel replacement, left upper lobe wedge resection, left phrenic nerve resection, left vagus nerve resection and partial pericardectomy.Conclusions: To the best of our knowledge, this is the sixth atypical carcinoid occurring in mediastinum with proof via histology and IHC. Our findings suggest the difficulty of making a diagnosis before surgery and more cases will need to be reported in order to facilitate the preoperative diagnosis of such a rare tumor.


CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A1555
Author(s):  
Stephen Mitchell ◽  
John Wynne ◽  
Joseph Flynn

2021 ◽  
Author(s):  
Alberto Testori ◽  
Vittorio Perfetti ◽  
Camilla De Carlo ◽  
Paola Bossi ◽  
Marco Alloisio ◽  
...  

2021 ◽  
pp. 014556132110248
Author(s):  
Yue Hu ◽  
Xing Guo ◽  
Feifei Jiang ◽  
Aihui Yan

Neuroendocrine carcinomas are a spectrum of rare and highly heterogeneous malignant tumors. Neuroendocrine carcinomas mainly arise from neuroendocrine cells scattered throughout the body. They mainly occur in the lung and gastrointestinal tract. Atypical carcinoid of the larynx is a rare type of neuroendocrine carcinoma, which is easily misdiagnosed as hemangioma in appearance. We mainly feature the disease to you through the diagnosis and treatment of a case of atypical carcinoid of the larynx.


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