Granulosa Cell Tumor of the Adult Type

Abstract We report a case of testicular granulosa cell tumor of the adult type in a 48-year-old man. Microscopically, the tumor consisted of round to ovoid cells with grooved nuclei that were arranged in several patterns, including microfollicular, macrofollicular, insular, trabecular, gyriform, solid, and pseudosarcomatous. These cells demonstrated strong immunopositivity with MIC2 (O13) antibody, vimentin, and smooth muscle actin and focal positivity with cytokeratin. Although this type of sex cord–stromal tumor is relatively common in the ovaries, it is still extremely unusual in the testis, and it probably represents the rarest type of testicular sex cord–stromal tumor.

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Pediatric Sex Cord-Stromal Tumor with Composite Morphology: A Case Report

Pediatric and Developmental Pathology ◽

10.1007/s10024-005-0055-2 ◽

2005 ◽

Vol 8 (6) ◽

pp. 680-684 ◽

Cited By ~ 2

Author(s):

Jason A. Jarzembowski ◽

Richard W. Lieberman

Keyword(s):

Granulosa Cell ◽

Sertoli Cell ◽

S100 Protein ◽

Neuron Specific Enolase ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Stromal Tumor ◽

Ca 125 ◽

Sertoli Cell Tumor ◽

Sex Cord Stromal Tumor

A 12-year-old female with developmental delay/mental retardation and a family history of gynecologic cancers presented with nonspecific abdominal complaints and was found to have a 4.5-kg, 25- x 23- x 15-cm pelvic mass with solid and cystic components and associated retro-peritoneal and mesenteric lymphadenopathy. Laboratory studies revealed increased serum levels of CA-125 and inhibin B. Histologically, the tumor exhibited several different morphologic appearances including adult granulosa cell tumor, juvenile granulosa cell tumor (with areas of marked atypia), and Sertoli cell tumor. Immunohistochemically, the tumor was positive for calretinin, MIC-2 (CD99), S100 protein, PGP 9.5, and neuron-specific enolase. Electron microscopy of the Sertoli cell tumor-like areas showed Charcot-Bottcher filaments, a distinguishing feature of Sertoli cells. Together, these findings supported a diagnosis of mixed sex cord-stromal tumor including granulosa cell tumor of adult and juvenile types and intermediate- to high-grade Sertoli cell tumor, with large areas of markedly atypical sex cord-stromal tumor.

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Biphasic Malignant Testicular Sex Cord-Stromal Tumor in a Cotton-top Tamarin (Saguinus oedipus) with Review of the Literature

Veterinary Pathology ◽

10.1354/vp.45-6-922 ◽

2008 ◽

Vol 45 (6) ◽

pp. 922-927 ◽

Cited By ~ 4

Author(s):

J. H. Yearley ◽

N. King ◽

X. Liu ◽

E. H. Curran ◽

S. P. O'Neil

Keyword(s):

Granulosa Cell ◽

Abdominal Mass ◽

Granulosa Cell Tumor ◽

Needle Aspiration ◽

Cell Tumor ◽

Stromal Tumor ◽

Histologic Examination ◽

Saguinus Oedipus ◽

Abdominal Tumor ◽

Sex Cord Stromal Tumor

A 20–year old male cotton-top tamarin ( Saguinus oedipus) was presented with unilateral enlargement of an intrascrotal testicle. Fine-needle aspiration cytology demonstrated a neoplastic population with Call-Exner-like bodies and features of malignancy. The animal was castrated, and histologic examination revealed a biphasic sex cord-stromal tumor, with one region resembling Sertoli-cell tumor and one region resembling granulosa-cell tumor, with extensive microfollicular pattern and many Call-Exner bodies. Eight months after castration, the animal was euthanized on discovery of a caudal abdominal mass that displaced organs, was highly infiltrative, and extended into the paravertebral musculature with lysis of vertebral bone. Metastases to lymph node and lung were also present. Histologic examination of the abdominal tumor showed multifocal formation of Call-Exner bodies in an otherwise highly dedifferentiated population. Positive immunolabeling for alpha inhibin confirmed the sex cord-stromal origin of the abdominal and paravertebral tumor masses. This case has similarities to malignant testicular granulosa-cell tumor of humans.

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Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature

Case Reports in Pathology ◽

10.1155/2013/932086 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Dimosthenis Miliaras ◽

Eleftherios Anagnostou ◽

Ioannis Moysides

Keyword(s):

Granulosa Cell ◽

Smooth Muscle Actin ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Placental Alkaline Phosphatase ◽

Alpha Smooth Muscle Actin ◽

Adult Type ◽

Left Testis ◽

Juvenile Type ◽

Potentially Malignant

Granulosa cell tumor (GST) is a sex-cord/stromal neoplasm of the gonads, more commonly arising in the ovaries, while approximately 80 cases have been reported in the testes. Out of these, 30 cases were of the adult type, while the remainder 50 cases were of the juvenile type. The latter mostly concerned infants and followed a benign course. However, the adult type testicular GCTs may be potentially malignant as it also happens in female patients with such neoplasms. We present a case of an adult type GCT located at the left testis. The patient was subjected to total orchiectomy and received no further treatment. Histology showed typical GCT histomorphology with Call-Exner bodies in some places. The immunoprofile of the tumor was CD99 (+), calretinin (+), inhibin (+), alpha smooth muscle actin (+), vimentin (+), ER (−), PR (−), keratin AE1/AE3 (−), alpha fetoprotein (−), CD117 (−), and placental alkaline phosphatase (−). Two years after surgery, the patient is alive and well with no signs of recurrence.

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