Primary Pleural Synovial Sarcoma

2003 ◽  
Vol 127 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Siok Bian Ng ◽  
Qasim Ahmed ◽  
Sim Leng Tien ◽  
Christina Sivaswaren ◽  
Lai Ching Lau
Keyword(s):  
Young Adults ◽  
In Situ Hybridization ◽  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Fluorescent In Situ Hybridization ◽  
Soft Tissue Tumor ◽  
Differential Diagnoses ◽  
Positive Staining ◽  
Rare Occurrence

Abstract Synovial sarcoma (SS) is an uncommon soft tissue tumor that occurs primarily in the extremities of young adults, especially in the periarticular region. In this report, we describe the rare occurrence of primary SS of the pleura in a 15-year-old boy. Histologically, the tumor demonstrated monophasic morphologic findings and showed positive staining with vimentin and Bcl-2 and focally for cytokeratin CK7. Fluorescent in situ hybridization identified t(X;18) translocation. The patient developed recurrences 20 months following resection of the tumor. The literature on this uncommon entity is reviewed, and its histogenesis, differential diagnoses, and cytologic features are also discussed.

scholarly journals Primary Cystic Pleuropulmonary Synovial Sarcoma Presenting as Recurrent Pneumothorax

2017 ◽  
Vol 10 (2) ◽  
pp. 660-665
Author(s):  
Eric D. Johnson ◽  
Erinn Downs-Kelly ◽  
David A. Bull ◽  
H. Evin Gulbahce
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
Synovial Sarcoma ◽  
Fluorescent In Situ Hybridization ◽  
Mass Lesion ◽  
Recurrent Pneumothorax ◽  
Synovial Sarcomas

Primary pleuropulmonary synovial sarcomas are quite rare, representing 0.1–0.5% of all pulmonary malignancies. We report an entirely cystic monophasic synovial sarcoma in a 25-year-old male who presented with recurrent pneumothorax and no evidence of a mass lesion on imaging. The purpose of this case report is to increase awareness of neoplasms clinically presenting as a pneumothorax with no imagining evidence of a mass-forming lesion and emphasize the significance of fluorescent in situ hybridization testing in nontypical synovial sarcoma cases.

scholarly journals Complete resection of a primitive neuroectodermal tumour arising in the bladder of a 31-year-old female after neoadjuvant chemotherapy

2016 ◽  
Vol 10 (7-8) ◽  
pp. 264 ◽  
Author(s):  
Cameron J. Lam ◽  
Bobby Shayegan
Keyword(s):  
In Situ Hybridization ◽  
Neoadjuvant Chemotherapy ◽  
Urinary Bladder ◽  
Fluorescent In Situ Hybridization ◽  
Complete Resection ◽  
Chromosomal Translocations ◽  
Rare Occurrence ◽  
Gross Hematuria ◽  
Primitive Neuroectodermal Tumour

Primitive neuroectodermal tumours (PNET) that arise in the urinary bladder are an extremely rare occurrence. Very few cases have been reported so far in the literature1-13 and we report another case here in a 31-year-old-female. The patient presented with polyuria, gross hematuria, followed by development of anuria, and was discovered to have a 9.4 cm mass arising in the posterolateral aspect of the bladder. Histologically, the tumour showed small, round, blue cells. Further analysis using break-apart fluorescent in situ hybridization (FISH) revealed non-random chromosomal translocations of the ews gene suggestive of Ewing sarcoma (ES)/ PNET. The patient completed seven cycles of neoadjuvant chemotherapy, which significantly reduced the size of the lesion. Due to the location of the lesion, surgical resection of the entire bladder and urethra with use of a continent cutaneous reservoir was performed. Here, the management of a 31-year-old female with ES/ PNET arising from the bladder is reported.

Relevance of cytogenetic and fluorescent in situ hybridization analyses in the clinical assessment of soft tissue sarcoma

1997 ◽  
Vol 28 (2) ◽  
pp. 134-142 ◽  
Author(s):  
Gabriella Sozzi ◽  
Fabiola Minoletti ◽  
Monica Miozzo ◽  
Laura Sard ◽  
Katia Musso ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Clinical Assessment ◽  
Fluorescent In Situ Hybridization

1796: Analysis of Chromosomal Aneuploidy in Patients with Oligoasthenoteratozoospermia(OAT) Using Fluorescent in-situ Hybridization

2007 ◽  
Vol 177 (4S) ◽  
pp. 596-597
Author(s):  
Joseph P. Alukal ◽  
Bobby B. Najari ◽  
Wilson Chuang ◽  
Lata Murthy ◽  
Monica Lopez-Perdomo ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescent In Situ Hybridization ◽  
Chromosomal Aneuploidy

Fluorescent in situ hybridization (FISH): A useful diagnostic tool for childhood conjunctival melanoma

2021 ◽  
pp. 112067212110307
Author(s):  
Raquel María Moral ◽  
Carlos Monteagudo ◽  
Javier Muriel ◽  
Lucía Moreno ◽  
Ana María Peiró
Keyword(s):  
In Situ Hybridization ◽  
Fluorescent In Situ Hybridization ◽  
Pediatric Population ◽  
Diagnostic Technique ◽  
Histopathological Diagnosis ◽  
Fish Analysis ◽  
Conjunctival Melanoma ◽  
Adequate Treatment ◽  
First Case

Introduction: Conjunctival melanoma is extremely rare in children and has low rates of resolution. Definitive histopathological diagnosis based exclusively on microscopic findings is sometimes difficult. Thus, early diagnosis and adequate treatment are essential to improve clinical outcomes. Clinical case: We present the first case in which the fluorescent in situ hybridization (FISH) diagnostic technique was applied to a 10-year-old boy initially suspected of having amelanotic nevi in his right eye. Based on the 65% of tumor cells with 11q13 (CCND1) copy number gain and 33% with 6p25 (RREB1) gain as measured by the FISH analysis, and on supporting histopathological findings, the diagnosis of conjunctival melanoma could be made. Following a larger re-excision, adjuvant therapy with Mitomycin C (MMC), cryotherapy and an amniotic membrane graft, the patient has remained disease-free during 9 years of long-term follow-up. Case discussion: Every ophthalmologist should remember to consider and not forget the possibility of using FISH analyses during the differential diagnosis of any suspicious conjunctival lesions. Genetic techniques, such as FISH, have led to great advances in the classification of ambiguous lesions. Evidence-based guidelines for diagnosing conjunctival melanoma in the pediatric population are needed to determine the most appropriate strategy for this age group.

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