Do Citizens of a City that Owns a Local Public Airport Have Attachment to the Airport and Use it?

This research investigates whether passengers living in a city with a local public airport have an attachment to that airport and tend to use it. Focusing on the greater Kansai area with its three airports and Kobe, which owns one of them, Kobe Airport, as an example, an empirical analysis was conducted using a nested logit model and micro data. The result of the basic model shows that passengers living in Kobe prefer the Kobe Airport when compared to passengers living in other cities. An additional analysis based on a questionnaire survey revealed that a certain percentage of respondents choose Kobe Airport because they love it, meaning that the non-economic factor of attachment influences passengers’ decisions. The results of this research suggest that enhancing attachment to an airport might be a possible idea for policy makers of airport cities to increase their passengers.

On the Intersectional Amplification of Barriers to College Internships: A Comparative Case Study Analysis

In this article, authors Matthew Wolfgram, Brian Vivona, and Tamanna Akram present a comparative case study analysis of five students from a comprehensive, urban Hispanic-Serving Institution whose experiences exemplify a coordination of intersectional factors that amplify barriers to internship participation. Research shows that college internships yield academic, economic, and professional benefits. However, the opportunity to locate and participate in internships is not equal across student demographic and socioeconomic contexts. There are multiple complex barriers to internship participation for students who are socially and institutionally minoritized by race, gender, and other contextual factors, including finances, work responsibilities, travel, and gendered familial obligations. These factors intersect with systems of power and privilege to amplify challenges and foreclose futures. The authors argue that the delineation of barriers into types alone, such as financial, social, and cultural, without additional analysis of the dynamics of how such barriers intersect and amplify, runs the risk of misconstruing students’ actual experiences when they struggle to access internships and other educational opportunities.

Defectoscopic and Geometric Features of Defects That Occur in Sheet Metal and Their Description Based on Statistical Analysis

Features of the defect class “scratches, attritions, lines”, their geometric structure, and their causes are analyzed. An approach is developed that defines subclasses within this class of technological defects based on additional analysis of morphological features. The analysis of the reasons for these subclasses allows additional information to be obtained about the rolling process, identifying additional signs of defects, regulating the rolling conditions of steel strips more accurately, and diagnosing the equipment condition.

Virtue, Sanctity, and Charity of the Royal Women of Fez

The history of the Banū Marīn of the kingdom of Fez (seventh–ninth/thirteenth–fifteenth centuries) cannot and should not be reconstructed without a gender perspective which gives the women of this dynasty a place within its historic discourse. They played a key role in the political and religious legitimacy of the rulers, as reflected by the Banū Marīn historiography which, mirroring the idiosyncrasy of medieval Berber societies, afforded its women a visible space. However, as it was always subject to the clear interests of male political-religious legitimacy, this space for visibilisation is worthy of analysis. This study examines the different profoundly religious behaviour and capabilities which the chronicles assigned to different royal Merinid women, as related in the various anecdotes transmitted in their pages. Additional analysis is carried out on how these model characterisations aimed to increase the aura of spirituality of the amīrs, influenced by their close relationship and everyday contact with these women.

525. Atovaquone for Treatment of COVID-19 (Ataq COVID-19) Trial

Background Our group performed an in-silico screen to identify FDA approved drugs that inhibit SARS-C0V-2 main protease (Mpro), followed by in vitro viral replication assays, and in vivo pharmacokinetic studies in mice. These studies identified atovaquone as a promising candidate for inhibiting viral replication. Methods Enrolled patients were randomized in a 2:1 fashion to atovaquone 1500 mg twice daily versus matched placebo. Patients received standard of care treatment including remdesivir, dexamethasone, or convalescent plasma as deemed necessary by the treating team. Patients agreed to allow collection of saliva at baseline and twice a day while hospitalized or up to 10 days. Saliva was collected and RNA extracted for viral load (VL) measurement by Real-time PCR. Our primary outcome was to examine the between group differences in log transformed VL(copies/mL) using generalized linear mixed-effect models of repeated measures from all samples. Additional analysis of Atovquone plasma concentrations were examined and correlated with viral load and body mass index (BMI). Results Of the 61 patients enrolled; 41 were received atovaquone and 19 placebo. Overall the population was predominately male Hispanic with a mean age of 51 years. The two groups were balanced (Table 1) with regard to age, gender, race, co-morbidities, days from onset of symptoms, baseline oxygen requirements, and receipt of COVID-19 specific standard of care treatment. A higher proportion with diabetes was noted in the Atovaquone arm. The log10 VL was 5.25 copies/mL vs. 4.79 copies/mL at baseline in the atovaquone vs. placebo group. Although there was a decrease in VL over time, there was no differences between the atovaquone plus standard of care arm versus the standard of care arm (Figure 1). Additional analysis of atovaquone plasma concentration demonstrated a wide variation in atovaquone levels, inverse association between atovaquone levels and BMI (rho -0.44, p=0.03), and Day 5 concentrations and VL (rho -0.54, p=0.005). Figure 1. Mean viral load of COVID-19 over time of atovaquone (blue) vs. placebo (red). Table 1. Baseline characteristics Conclusion Although atovaquone showed promising in vitro antiviral properties for COVID-19, in this pilot study we did not detect a change in VL in patients who received atovaquone compared to placebo, possibly due to failure of patients achieve adequate drug levels. Disclosures Mamta K. Jain, MD, MPH, Gilead Sciences Inc. (Individual(s) Involved: Self): Research Grant or Support, Scientific Research Study Investigator; GlaxoSmithKline (Individual(s) Involved: Self): Scientific Research Study Investigator; Merck (Individual(s) Involved: Self): Scientific Research Study Investigator; Vasgene (Individual(s) Involved: Self): Scientific Research Study Investigator

Three-Dimensional Modelling of Spatial Data in Urban Territory

The content of the research is divided into four points. The first part considers the need of 3D models creation - good practices applied in different countries related to Internet services for urban development and planning, preservation of cultural heritage, as well as scientific research. The second part focuses on the nature of 3D modeling, addressing theoretical issues concerning conceptual modeling, classification of three-dimensional models, geometry and topology. Different data formats are described. The third part focuses on an overview of the different 3D data sources and 3D modeling methods. The fourth part includes the description of a specific software for creating, editing and presenting 3D models - City Engine. The functionality, the specific possibilities for additional analysis and extraction of attribute information from the created models are described, as well as the programming language used in creating three-dimensional models in the software environment. In the fourth part, practical tasks are performed, which aim to make a comparison between the actual state of construction with the set project values in the general development plan for Sofia Municipality. 3D models of buildings in a neighbourhood in the Lozenets region were created, after which an additional analysis of the current state of construction was performed. The possibilities of the software for automatic generation of a street network are considered, as well as the functionality related to the modeling of facades.

Identification of Potential Citrate Metabolism Pathways in Carnobacterium maltaromaticum

In the present study, we describe the identification of potential citrate metabolism pathways for the lactic acid bacterium (LAB) Carnobacterium maltaromaticum. A phenotypic assay indicated that four of six C. maltaromaticum strains showed weak (Cm 6-1 and ATCC 35586) or even delayed (Cm 3-1 and Cm 5-1) citrate utilization activity. The remaining two strains, Cm 4-1 and Cm 1-2 gave negative results. Additional analysis showed no or very limited utilization of citrate in media containing 1% glucose and 22 or 30 mM citrate and inoculated with Cm 6-1 or ATCC 35586. Two potential pathways of citrate metabolism were identified by bioinformatics analyses in C. maltaromaticum including either oxaloacetate (pathway 1) or tricarboxylic compounds such as isocitrate and α-ketoglutarate (pathway 2) as intermediates. Genes encoding pathway 1 were present in two out of six strains while pathway 2 included genes present in all six strains. The two potential citrate metabolism pathways in C. maltaromaticum may potentially affect the sensory profiles of milk and soft cheeses subjected to growth with this species.

Do Revenues Matter More Than Earnings for Initial Public Offerings?

We demonstrate that investors in initial public offering (IPO) firms value revenues and that the number of U.S. Securities and Exchange Commission (SEC) revenue recognition comment letters issued on the S-1 registration statement are positively associated with reported revenues. We also find that IPO managers report revenues opportunistically in the fiscal year just prior to the offer. In additional analysis, we find that discretionary revenues are associated with significantly higher first day IPO stock returns but significantly lower 1 year stock returns. Our results are consistent with the incentives of managers to report revenues opportunistically outweighing the higher monitoring and regulatory scrutiny pre-IPO.

Methodological Aspects of Using Mechanism of Financing Projects Based on State and Private Partnership

The article provides a detailed analysis of key methods to assess the efficiency of projects based on state and private partnership (S&PP), including the appraisal of commercial, social-economic, macro-economic and budget efficiency. For such projects implemented on principles of project financing the authors highlighted the necessity of additional analysis of finance stability and return of credit financing. The article gives the author's definition of the mechanism of financing S&PP projects and explains methodological characteristics of assessing their efficiency for different participants and in interests of different concerned parties (state, business, banks). Special attention is paid to detailed study of the technology of calculating each parameter of assessing the efficiency for investment S&PP projects. Finally, conclusions were drawn about practical opportunities to use all the parameters, demonstrated above to assess the efficiency of projects in Russia, as well as key difficulties arising in the process of analysis and appraisal.

Circuit motifs and graph properties of connectome development in C. elegans

Network science is a powerful tool that can be used to better explore the complex structure of brain networks. Leveraging graph and motif analysis tools, we interrogate C. elegans connectomes across multiple developmental time points and compare the resulting graph characteristics and substructures over time. We show the evolution of the networks and highlight stable invariants and patterns as well as those that grow or decay unexpectedly, providing a substrate for additional analysis.