Adenocarcinoma of the Urinary Bladder

Primary adenocarcinoma of urinary bladder is an uncommon neoplasm and is a source of diagnostic confusion with adenocarcinomas arising in adjacent organs, especially colon. These tumors show varied histologic picture and degree of differentiation. Clinical association with bladder exstrophy and schistosomiasis has been well documented. Primary bladder adenocarcinomas have overlapping histologic and immunohistochemical features with adenocarcinomas arising from other primary sites and the suggested immunohistochemical panel includes cytokeratins 7 and 20, 34βE12, thrombomodulin, CDX2, and β-catenin. Clinical, imaging, histologic, and immunohistochemical correlation should be done while rendering this diagnosis, as prognosis and therapeutic options for primary versus metastatic adenocarcinoma vary widely.

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Primary Adenocarcinoma of the Urinary Bladder: Differential Diagnosis and Clinical Relevance

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2012-0076-ra ◽

2013 ◽

Vol 137 (3) ◽

pp. 371-381 ◽

Cited By ~ 24

Author(s):

Minghao Zhong ◽

Elizabeth Gersbach ◽

Stephen M. Rohan ◽

Ximing J. Yang

Keyword(s):

Differential Diagnosis ◽

Urinary Bladder ◽

Urothelial Carcinoma ◽

World Health ◽

Primary Adenocarcinoma ◽

Secondary Malignancies ◽

Nephrogenic Adenoma ◽

Urachal Remnant ◽

Primary Bladder ◽

Bladder Adenocarcinoma

Context.—Glandular lesions of the urinary bladder include a broad spectrum of entities ranging from completely benign glandular lesions to primary and secondary malignancies. Common benign bladder lesions that exhibit glandular differentiation include cystitis cystica, cystitis glandularis, von Brunn nests, nephrogenic adenoma, intestinal metaplasia, urachal remnant, endometriosis, and prostatic-type polyp. The World Health Organization defines primary adenocarcinoma of the bladder as an epithelial malignancy with pure glandular differentiation without evidence of typical urothelial carcinoma. Malignant lesions that should be included in the differential diagnosis of a primary adenocarcinoma of the bladder include noninvasive and invasive urothelial carcinoma with glandular differentiation and secondary malignancies involving the bladder by direct extension or metastasis. The recognition and distinction of these different entities may be a challenge for pathologists, but they are of great clinical importance. Objective.—To review features of primary bladder adenocarcinoma as well as those entities that need to be differentiated from primary bladder adenocarcinoma, with emphasis on clinical findings, pathologic characteristics, and immunoprofiles. Data Sources.—Selected original articles published in the PubMed service of the US National Library of Medicine. Conclusions.—The accurate diagnosis of adenocarcinoma of the urinary bladder is important and challenging. It has to prompt an extensive clinical workup to rule out other glandular lesions in the urinary bladder, especially the possibility of secondary involvement of the bladder by an adenocarcinoma from a different site.

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Mucin histochemistry in primary adenocarcinoma of the urinary bladder (of urachal or vesicular origin) and metastatic adenocarcinoma originating in the colorectum

Pathology International ◽

10.1046/j.1440-1827.2000.01049.x ◽

2000 ◽

Vol 50 (4) ◽

pp. 297-303 ◽

Cited By ~ 9

Author(s):

Kuniaki Nakanishi ◽

Susumu Tominaga ◽

Toshiaki Kawai ◽

Chikao Torikata ◽

Takashi Aurues ◽

...

Keyword(s):

Urinary Bladder ◽

Primary Adenocarcinoma ◽

Metastatic Adenocarcinoma ◽

Mucin Histochemistry

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Bladder exstrophy with inguinal hernia: a case report

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20201656 ◽

2020 ◽

Vol 7 (5) ◽

pp. 1155

Author(s):

Tazeem Fatima Ansari ◽

Prachi Gandhi ◽

Poonam Wade ◽

Vinaya Lichade Singh ◽

Kiran Khedkar ◽

...

Keyword(s):

Inguinal Hernia ◽

Urinary Bladder ◽

Bladder Neck ◽

Inguinal Canal ◽

Bladder Exstrophy ◽

Pubic Symphysis ◽

Pubic Diastasis ◽

Primary Bladder ◽

Staged Reconstruction ◽

Lower Abdominal Wall

Exstrophy of urinary bladder with epispadias involves protrusion of the urinary bladder through a defect in the lower abdominal wall accompanied by separation of pubic symphysis. It is a rare but challenging condition that causes significant physical, functional, social, sexual and psychological problems later in life. Bladder exstrophy commonly involves males and most cases are sporadic. Inguinal hernia is a complication associated with bladder exstrophy and it occurs due to lack of obliquity of the inguinal canal secondary to pubic diastasis. Authors report here, a case of antenatally diagnosed case of classic bladder exstrophy associated with left sided inguinal hernia which was incidentally diagnosed on tenth day of life. Our neonate underwent primary bladder closure with herniotomy. Staged reconstruction of epispadias and bladder neck has been planned at a later date. Recurrence of inguinal hernia after repair is common and bilateral inguinal exploration while performing herniotomy is advised to prevent its recurrence. Prognosis of such cases depends on the degree of continence achieved. With timely reconstructive surgery, continence rates can be as high as 60-70 percent.

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Ultrastructure of mesotheliomas

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100110775 ◽

1984 ◽

Vol 42 ◽

pp. 98-101

Author(s):

Irving Dardick

Keyword(s):

Electron Microscopy ◽

Latent Period ◽

Spindle Cell ◽

Spindle Cell Sarcoma ◽

Metastatic Adenocarcinoma ◽

Cell Sarcoma ◽

Cytological Features ◽

Industrial Use ◽

Degree Of Differentiation

With the extensive industrial use of asbestos in this century and the long latent period (20-50 years) between exposure and tumor presentation, the incidence of malignant mesothelioma is now increasing. Thus, surgical pathologists are more frequently faced with the dilemma of differentiating mesothelioma from metastatic adenocarcinoma and spindle-cell sarcoma involving serosal surfaces. Electron microscopy is amodality useful in clarifying this problem.In utilizing ultrastructural features in the diagnosis of mesothelioma, it is essential to appreciate that the classification of this tumor reflects a variety of morphologic forms of differing biologic behavior (Table 1). Furthermore, with the variable histology and degree of differentiation in mesotheliomas it might be expected that the ultrastructure of such tumors also reflects a range of cytological features. Such is the case.

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