A Short-Term In Vivo Evaluation of the Istanbul Heart Left Ventricular Assist Device in a Pig Model

2019 ◽  
Author(s):  
Ismail Lazoglu ◽  
Deniz Suha Kucukaksu ◽  
Caglar Ozturk ◽  
Ibrahim Basar Aka ◽  
Vedat Bakuy ◽  
...  
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Pig Model ◽  
Short Term ◽  
Assist Device ◽  
In Vivo Evaluation ◽  
Ventricular Assist ◽  
Left Ventricular Assist

Short-Term In Vivo Performance of the Cleveland Clinic PediPump Left Ventricular Assist Device

2013 ◽  
Vol 38 (5) ◽  
pp. 374-382 ◽  
Author(s):  
Hideyuki Fumoto ◽  
Akira Shiose ◽  
Christine R. Flick ◽  
Lawrence D. Noble ◽  
David T. Dudzinski ◽  
...  
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Cleveland Clinic ◽  
Left Ventricular ◽  
Short Term ◽  
Assist Device ◽  
Ventricular Assist ◽  
Left Ventricular Assist

In Vivo Evaluation of the “TinyPump” as a Pediatric Left Ventricular Assist Device

2011 ◽  
Vol 35 (5) ◽  
pp. 543-553 ◽  
Author(s):  
Takashi Kitao ◽  
Yusuke Ando ◽  
Masaharu Yoshikawa ◽  
Mariko Kobayashi ◽  
Taro Kimura ◽  
...  
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Assist Device ◽  
In Vivo Evaluation ◽  
Ventricular Assist ◽  
Left Ventricular Assist

scholarly journals Initial In Vivo Evaluation of a Novel Left Ventricular Assist Device

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Guanghui Wu ◽  
Changyan Lin ◽  
Haiyang Li ◽  
Xiaotong Hou ◽  
Chen Chen ◽  
...  
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Thrombus Formation ◽  
Left Ventricular ◽  
Magnetic Suspension ◽  
Assist Device ◽  
In Vivo Evaluation ◽  
Ventricular Assist ◽  
Left Ventricular Assist

The aim of the study was to use the ovine model to evaluate the hemocompatibility and end-organ effects of a newly developed magnetic suspension centrifugal left ventricular assist device (LVAD) by CH Biomedical Inc., Jiangsu, China. The LVADs were implanted in 6 healthy sheep, where inflow was inserted into the left ventricular apex and outflow was anastomosed to the descending aorta. All sheep received anticoagulation and antiaggregation therapy during the study. Hematologic and biochemical tests were performed to evaluate anemia, hepatorenal function, and the extent of hemolysis. The experiments lasted for up to 30 days on the beating hearts. All sheep were humanely killed at the termination of the experiments, and the end-organs were examined macroscopically and histopathologically. Autopsy was performed in all animals and there was no thrombus formation observed inside the pump. The pump’s inflow and outflow conduits were also free of thrombus. Hematologic and biochemical test results were within normal limits during the study period. Postmortem examination of the explanted organs revealed no evidence of ischemia or infarction. Based on the in vivo study, this LVAD is suitable for implantation and can provide efficient support with good biocompatibility. The encouraging results in this study suggest that it is feasible to evaluate the device’s long-term durability and stability.

In vivo testing of a pulsatile implantable impeller pump as a left ventricular assist device used in calves

Perfusion ◽  
1995 ◽  
Vol 10 (4) ◽  
pp. 257-263 ◽  
Author(s):  
KX Qian ◽  
SS Wang ◽  
SH Chu
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Assist Device ◽  
Ventricular Assist ◽  
Left Ventricular Assist ◽  
Mean Pressure ◽  
In Vivo Testing ◽  
Serum Glutamic Oxalacetic Transaminase

A pulsatile implantable impeller pump was tested as a left ventricular assist device in five calves. The experiments lasted for 4-11 days. Death or termination was mainly due to respiratory complications or bleeding, irrelevant to the pump itself. As indicators of haemolysis, thrombogenesis, renal and hepatic functions, free haemoglobin( FHb), haematocrit (Hct), platelet number (Plt), lactate dehydrogenase (LDH), blood urea nitrogen (BUN), creatinine, serum glutamic oxalacetic transaminase (GOT) and total bilirubin were measured preoperatively, at the beginning of the pumping (pump on), six hours later and every day thereafter. The data indicated that the pump caused no severe blood damage or organ dysfunction. Thus, the feasibility of a pulsatile centrifugal pump was demonstrated. The pump with its driver weighs 110 g and is capable of delivering a blood flow up to 8 l/min against 100 mmHg mean pressure.

Short-Term Experience with Off-Pump Versus On-Pump Implantation of the HeartWare Left Ventricular Assist Device

ASAIO Journal ◽  
2017 ◽  
Vol 63 (1) ◽  
pp. 68-72 ◽  
Author(s):  
Igor D. Gregoric ◽  
Rajko Radovancevic ◽  
Mehmet H. Akay ◽  
Mateja K. Jezovnik ◽  
Sriram Nathan ◽  
...  
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Short Term ◽  
Assist Device ◽  
Ventricular Assist ◽  
Off Pump ◽  
Left Ventricular Assist ◽  
Pump Implantation
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