Liver Transplantation for Rapidly Progressive Giant Hepatic Hemangioma With Diffuse Hemangiomatosis

We present a case of giant cavernous hemangioma of the liver with disseminated intravascular coagulopathy (Kasabach–Merritt syndrome) which was cured by enucleation. The 51 year old woman presented with increased abdominal girth and easy bruisability. Workup elsewhere revealed a massive hepatic hemangioma and she was started on radiation therapy to the lesion and offered an orthotopic liver transplant. After careful preoperative preparation, we felt that resection was possible and she underwent a successful enucleation. The operation and postoperative course were complicated by bleeding but she recovered and remains well in followup after 6 months. All coagulation parameters have returned to normal. Enucleation should be considered the treatment of choice for hepatic hemangiomas, including those presenting with Kasabach–Merritt syndrome. The benefits of enucleation as compared to liver transplantation for these lesions are discussed.

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Living donor liver transplantation in a patient with giant hepatic hemangioma complicated by Kasabach-Merritt syndrome: Report of a case

Surgery Today ◽

10.1007/s00595-007-3623-4 ◽

2008 ◽

Vol 38 (5) ◽

pp. 463-468 ◽

Cited By ~ 31

Author(s):

Makoto Meguro ◽

Yuji Soejima ◽

Akinobu Taketomi ◽

Toru Ikegami ◽

Yo-ichi Yamashita ◽

...

Keyword(s):

Liver Transplantation ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Hepatic Hemangioma ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Giant Hepatic Hemangioma ◽

Syndrome Report

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Living donor liver transplantation for giant hepatic hemangioma with Kasabach-Merritt syndrome with a posterior segment graft

Liver Transplantation ◽

10.1053/jlts.2002.33689 ◽

2002 ◽

Vol 8 (8) ◽

pp. 721-724 ◽

Cited By ~ 40

Author(s):

Y Kumashiro

Keyword(s):

Liver Transplantation ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Posterior Segment ◽

Hepatic Hemangioma ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Giant Hepatic Hemangioma

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Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult: a case report

Clinical and Molecular Hepatology ◽

10.3350/cmh.2017.0002 ◽

2018 ◽

Vol 24 (2) ◽

pp. 163-168 ◽

Cited By ~ 2

Author(s):

Ju Hyun Lee ◽

Chang Jin Yoon ◽

Young Hoon Kim ◽

Ho-Seong Han ◽

Jai Young Cho ◽

...

Keyword(s):

Liver Transplantation ◽

Case Report ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Hepatic Hemangioma ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Giant Hepatic Hemangioma

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Giant Hepatic Hemangioma Regressed Significantly Without Surgical Management: A Case Report and Literature Review

Frontiers in Medicine ◽

10.3389/fmed.2021.712324 ◽

2021 ◽

Vol 8 ◽

Author(s):

Jingcong Zhang ◽

Zuyang Ye ◽

Lei Tan ◽

Jinmei Luo

Keyword(s):

Cell Proliferation ◽

Liver Transplantation ◽

Case Report ◽

Literature Review ◽

Lymphatic Vessels ◽

Vascular Anomaly ◽

Endothelial Cell Proliferation ◽

Hepatic Hemangioma ◽

Specific Drug ◽

Giant Hepatic Hemangioma

Hepatic hemangioma (HH) is a congenital vascular anomaly comprising networks of abnormal blood and/or lymphatic vessels with endothelial cell proliferation. Their pathophysiology is not fully understood, and no specific drug is available to treat them. Conservative management, which limits observation, is preferred for most patients. A HH larger than 4 cm is considered a giant HH that may be treated using surgery ranging from embolization to hepatic resection or liver transplantation. Here, we describe a case with multiple and giant HHs that regressed significantly after treatment with azithromycin (AZM). A systematic literature review of HH and the effects of AZM on angiogenesis was then conducted.

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