scholarly journals Study on usefulness of heparin coating heart-lung machine circuit.

1999 ◽  
Vol 26 (2) ◽  
pp. 17-19
Author(s):  
SHIGEHIRO MOTOHASHI
Perfusion ◽  
1999 ◽  
Vol 14 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Hans P Wendel ◽  
Albertus M Scheule ◽  
Friedrich S Eckstein ◽  
Gerhard Ziemer

Extracorporeal circulation (ECC) in paediatric patients with heparin-coated oxygenation systems is rarely investigated. The objective of this study was to evaluate, preclinically, the haemocompatibility of paediatric membrane oxygenators with heparin-coated surfaces. We compared 16 paediatric membrane oxygenators (Minimax, Medtronic) in an in vitro heart-lung machine model with fresh human blood. Eight of these oxygenation systems had a covalent heparin coating (Carmeda bioactive surface). After 90 min simulated ECC, the heparin-coated systems showed significantly higher platelet count, lower platelet-factor 4 release, reduced contact activation (factor XIIa and kallikrein), and lower neutrophil elastase levels ( p < 0.05), compared to the noncoated oxygenator group. More biocompatible materials for paediatric operations may ameliorate the various postperfusion syndromes arising from ECC procedures, particularly unspecific inflammation, hyperfibrinolysis and blood loss.


1956 ◽  
Vol 32 (3) ◽  
pp. 410-416 ◽  
Author(s):  
Jackson H. Stuckey ◽  
Melvin M. Newman ◽  
Clarence Dennis ◽  
Bernard S. Levowitz ◽  
Harry N. Iticovici ◽  
...  

1959 ◽  
Vol 37 (2) ◽  
pp. 184-189 ◽  
Author(s):  
William W. Musicant ◽  
Reuben R. Lewis ◽  
Belmont S. Musicant ◽  
Robert M. Anderson ◽  
Jerome Harold Kay

1992 ◽  
Vol 104 (6) ◽  
pp. 1647-1653 ◽  
Author(s):  
Karl Q. Schwarz ◽  
Charles C. Church ◽  
Peter Serrino ◽  
Richard S. Meltzer

1959 ◽  
Vol 36 (4) ◽  
pp. 423-425
Author(s):  
JEROME HAROLD KAY ◽  
ROBERT M. ANDERSON ◽  
OSCAR MAGIDSON ◽  
JOHN E. MEIHAUS ◽  
REUBEN LEWIS ◽  
...  

BMJ ◽  
1969 ◽  
Vol 1 (5636) ◽  
pp. 104-104
Author(s):  
D. G. Melrose

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