scholarly journals NOCARDICIN A, A NEW MONOCYCLIC β-LACTAM ANTIBIOTIC. III

1977 ◽  
Vol 30 (11) ◽  
pp. 917-931 ◽  
Author(s):  
MINORU NISHIDA ◽  
YASUHIRO MINE ◽  
SHIGEO NONOYAMA ◽  
HITOSHI KOJO ◽  
SACHIKO GOTO ◽  
...  
Keyword(s):  
Nocardicin A ◽  
Lactam Antibiotic

scholarly journals Nocardicin A, a new monocyclic .BETA.-lactam antibiotic. VI. Absorption, excretion and tissue distribution in animals.

1977 ◽  
Vol 30 (11) ◽  
pp. 938-944 ◽  
Author(s):  
YASUHIRO MINE ◽  
SHIGEO NONOYAMA ◽  
HITOSHI KOJO ◽  
SHIGEMI FUKADA ◽  
MINORU NISHIDA ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Beta Lactam ◽  
Beta Lactam Antibiotic ◽  
Nocardicin A ◽  
Lactam Antibiotic

scholarly journals The Biosynthetic Gene Cluster for a Monocyclic β-Lactam Antibiotic, Nocardicin A

2004 ◽  
Vol 11 (7) ◽  
pp. 927-938 ◽  
Author(s):  
Michele Gunsior ◽  
Steven D Breazeale ◽  
Amanda J Lind ◽  
Jacques Ravel ◽  
James W Janc ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Nocardicin A ◽  
Lactam Antibiotic

scholarly journals Nocardicin a, a new monocyclic .BETA.-lactam antibiotic. I. Discovery, isolation and characterization.

1976 ◽  
Vol 29 (5) ◽  
pp. 492-500 ◽  
Author(s):  
HATSUO AOKI ◽  
HEI-ICHI SAKAI ◽  
MASANOBU KOHSAKA ◽  
TOSHIO KONOMI ◽  
JUNJI HOSODA ◽  
...  
Keyword(s):  
Beta Lactam ◽  
Beta Lactam Antibiotic ◽  
Isolation And Characterization ◽  
Nocardicin A ◽  
Lactam Antibiotic

scholarly journals Nature of Monocyclic β-Lactam Antibiotic Nocardicin A to β-Lactamases

1988 ◽  
Vol 32 (2) ◽  
pp. 119-130 ◽  
Author(s):  
Hitoshi Kojo ◽  
Yasuhiro Mine ◽  
Minoru Nishida ◽  
Sachiko Goto ◽  
Shogo Kuwahara
Keyword(s):  
Nocardicin A ◽  
Lactam Antibiotic

scholarly journals Nocardicin A, a new monocyclic .BETA.-lactam antibiotic. V. in vivo evaluation.

1977 ◽  
Vol 30 (11) ◽  
pp. 932-937 ◽  
Author(s):  
YASUHIRO MINE ◽  
SHIGEO NONOYAMA ◽  
HITOSHI KOJO ◽  
SHIGEMI FUKADA ◽  
MINORU NISHIDA ◽  
...  
Keyword(s):  
Beta Lactam ◽  
In Vivo Evaluation ◽  
Beta Lactam Antibiotic ◽  
Nocardicin A ◽  
Lactam Antibiotic

Effect of piperacillin on morphology and viability of gram-negative bacteria

1984 ◽  
Vol 42 ◽  
pp. 218-219
Author(s):  
R. H. Liss
Keyword(s):  
Inhibitory Concentration ◽  
Cytoplasmic Membrane ◽  
Drug Binding ◽  
Gram Negative Bacteria ◽  
Bacterial Cells ◽  
Drug Induced ◽  
Penicillin Binding Proteins ◽  
Lactam Antibiotic ◽  
Drug Free ◽  
Tube Dilution

Piperacillip (PIP) is b-[D(-)-α-(4-ethy1-2,3-dioxo-l-piperzinylcar-bonylamino)-α-phenylacetamido]-penicillanate. The broad spectrum semisynthetic β-lactam antibiotic is believed to effect bactericidal activity through its affinity for penicillin-binding proteins (PBPs), enzymes on the bacterial cytoplasmic membrane that control elongation and septation during cell growth and division. The purpose of this study was to correlate penetration and binding of 14C-PIP in bacterial cells with drug-induced lethal changes assessed by microscopic, microbiologic and biochemical methods.The bacteria used were clinical isolates of Escherichia coli and Pseudomonas aeruginosa (Figure 1). Sensitivity to the drug was determined by serial tube dilution in Trypticase Soy Broth (BBL) at an inoculum of 104 organisms/ml; the minimum inhibitory concentration of piperacillin for both bacteria was 1 μg/ml. To assess drug binding to PBPs, the bacteria were incubated with 14C-PIP (5 μg/0.09 μCi/ml); controls, in drug-free medium.

Non–β-Lactam Antibiotic Hypersensitivity Reactions

PEDIATRICS ◽  
2020 ◽  
Vol 146 (Supplement 4) ◽  
pp. S335.2-S336
Author(s):  
Alex Qian ◽  
Susan Laubach
Keyword(s):  
Hypersensitivity Reactions ◽  
Lactam Antibiotic
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