The Awareness of Beta-Lactam Antibiotics Prescription among Dental Students

Beta-lactam antibiotic is the most common antibiotic prescribed by dental students. However, the actual knowledge on beta lactam is important as antimicrobial resistance is currently an alarming and growing phenomenon and in turn becoming a public health challenge. A survey was conducted to assess the knowledge and awareness of beta-lactam antibiotics prescriptions among dental students in their third years, final years and interns. A total of 145 responses were obtained and the results were analyzed using the SPSS statistical software. Based on their knowledge on beta-lactam antibiotics, 59.3% of the participants knew exactly the mechanisms of action of beta-lactam antibiotic which was by interfering with the synthesis of the bacterial cell wall. In the case of penicillin allergy, 40% of the participants chose erythromycin as the alternative for penicillin allergy. 84% of the participants were aware that the combination of amoxicillin with clavulanic acid may increase its effectiveness. Meanwhile, 98% of the participants were aware that amoxicillin is the drug of choice for bacterial endocarditis prophylaxis. 72% of the participants were aware that most beta-lactam antibiotics are considered safe for pregnant and lactating women which was statistically significant (p<0.05). In conclusion, the students had quite a good knowledge and awareness regarding the prescription of beta-lactam antibiotics since they have been practicing under guidance from the practitioner in the college.

Amoxicillin induced toxic epidermal necrolysis

Toxic epidermal necrolysis (TEN) is a rare life-threatening adverse drug reaction associated with mucocutaneous eruptions and peeling of skin (sloughing) mostly caused by drugs like sulphonamides, beta lactams, carbamazepine and non-steroidal anti-inflammatory drugs (NSAIDs). Amoxicillin is a broad spectrum, bactericidal, Beta-lactam antibiotic used in treatment of various infections. Here by we have reported the case of amoxicillin induced severe toxic epidermal necrolysis. A Patient admitted in the hospital with the symptoms of epidermal sloughing that resulted in bare dermis as he received Amoxicillin drug for his diagnosis of fever. After clear examination TEN was confirmed and suspected with the cause due to Amoxicillin. The drug was stopped and patient was treated with other drugs for symptomatic cure. The patient was recovered from his condition and improved significantly.