scholarly journals Confirmation of the Antibacterial Mode of Action of SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp.

2002 ◽  
Vol 55 (4) ◽  
pp. 423-426 ◽  
Author(s):  
REBECCA C. GREENWOOD ◽  
DANIEL R. GENTRY
Keyword(s):  
Mode Of Action ◽  
Trna Synthetase ◽  
Synthetase Inhibitor

Synthesis of conformationally restricted analogues of the tryptophanyl tRNA synthetase inhibitor indolmycin

1996 ◽  
Vol 37 (17) ◽  
pp. 3067-3070 ◽  
Author(s):  
David R. Witty ◽  
Graham Walker ◽  
John H. Bateson ◽  
Peter J. O'Hanlon ◽  
Drake S. Eggleston ◽  
...  
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor ◽  
Conformationally Restricted

scholarly journals A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses

2019 ◽  
Vol 161 ◽  
pp. 163-168 ◽  
Author(s):  
Jesse Hwang ◽  
Alfred Jiang ◽  
Erol Fikrig
Keyword(s):  
Trna Synthetase ◽  
Dengue Viruses ◽  
Synthetase Inhibitor

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)

2017 ◽  
Vol 60 (19) ◽  
pp. 8011-8026 ◽  
Author(s):  
Xianfeng Li ◽  
Vincent Hernandez ◽  
Fernando L. Rock ◽  
Wai Choi ◽  
Yvonne S. L. Mak ◽  
...  
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor

Identification of the Enzymes Mediating the Maturation of the Seryl‐tRNA Synthetase Inhibitor SB‐217452 during the Biosynthesis of Albomycins

2020 ◽  
Vol 132 (9) ◽  
pp. 3586-3590
Author(s):  
Richiro Ushimaru ◽  
Zhang Chen ◽  
Houyuan Zhao ◽  
Po‐hsun Fan ◽  
Hung‐wen Liu
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor

Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l -proline

2017 ◽  
Vol 488 (2) ◽  
pp. 393-399 ◽  
Author(s):  
Ryutaro Adachi ◽  
Kengo Okada ◽  
Robert Skene ◽  
Kazumasa Ogawa ◽  
Masanori Miwa ◽  
...  
Keyword(s):  
Binding Mode ◽  
Trna Synthetase ◽  
Synthetase Inhibitor

scholarly journals Further Characterization ofBacillus subtilisAntibiotic Biosensors and Their Use for Antibacterial Mode-of-Action Studies

2011 ◽  
Vol 55 (4) ◽  
pp. 1784-1786 ◽  
Author(s):  
Katherine R. Mariner ◽  
Nicola Ooi ◽  
Deborah Roebuck ◽  
Alex J. O'Neill ◽  
Ian Chopra
Keyword(s):  
Bacillus Subtilis ◽  
Rna Polymerase ◽  
Mode Of Action ◽  
Trna Synthetase ◽  
Dna Intercalators ◽  
Peptidoglycan Synthesis ◽  
Modes Of Action ◽  
Polymerase Inhibitors

ABSTRACTWe further examined the usefulness of previously reportedBacillus subtilisbiosensors for antibacterial mode-of-action studies. The biosensors could not detect the tRNA synthetase inhibitors mupirocin, indolmycin, and borrelidin, some inhibitors of peptidoglycan synthesis, and most membrane-damaging agents. However, the biosensors confirmed the modes of action of several RNA polymerase inhibitors and DNA intercalators and provided new insights into the possible modes of action of ciprofloxacin, anhydrotetracycline, corralopyronin, 8-hydroxyquinoline, and juglone.

scholarly journals Biosynthesis of Albomycin δ2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates

2012 ◽  
Vol 7 (9) ◽  
pp. 1565-1575 ◽  
Author(s):  
Yu Zeng ◽  
Aditya Kulkarni ◽  
Zhaoyong Yang ◽  
Preeti B. Patil ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase ◽  
Synthetase Inhibitor

scholarly journals A Potent Seryl tRNA Synthetase Inhibitor SB-217452 Isolated from a Streptomyces species.

2000 ◽  
Vol 53 (12) ◽  
pp. 1346-1353 ◽  
Author(s):  
ANNA L. STEFANSKA ◽  
MARK FULSTON ◽  
CATHERINE S.V HOUGE-FRYDRYCH ◽  
Jo J. JONES ◽  
STEPHEN R. WARR
Keyword(s):  
Trna Synthetase ◽  
Streptomyces Species ◽  
Synthetase Inhibitor

Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207

2003 ◽  
Vol 11 (13) ◽  
pp. 2687-2694 ◽  
Author(s):  
Curtis F Crasto ◽  
Andrew K Forrest ◽  
Tomislav Karoli ◽  
Darren R March ◽  
Lucy Mensah ◽  
...  
Keyword(s):  
Trna Synthetase ◽  
Synthetase Inhibitor

A bisubstrate reagent orchestrating adenosine triphosphate and l-tyrosine and making tyrosyl adenylate: partial mimicking of tyrosyl-tRNA synthetase

2018 ◽  
Vol 16 (48) ◽  
pp. 9446-9453
Author(s):  
Harpreet Singh ◽  
Baljit Kaur ◽  
Harpreet Kaur ◽  
Palwinder Singh
Keyword(s):  
Adenosine Triphosphate ◽  
Mode Of Action ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase

Mimicking the catalytic mode of aminoacyl-tRNA synthetase, the mode of action of reagent 1 was orchestrated for the formation of 5′-aminoacyl adenylate.

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