Peer Review #2 of "Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study (v0.2)"

Background In China, there is insufficient evidence to support that screening programs can detect breast cancer earlier and improve outcomes compared with patient self-reporting. Therefore, we compared the pathological characteristics at diagnosis between self-detected and screen-detected cases of invasive breast cancer at our institution and determined whether these characteristics were different after the program’s introduction (vs. prior to). Methods Three databases were selected (breast cancer diagnosed in 1995–2000, 2010, and 2015), which provided a total of 3,014 female patients with invasive breast cancer. The cases were divided into self-detected and screen-detected groups. The pathological characteristics were compared between the two groups and multiple imputation and complete randomized imputation were used to deal with missing data. Results Compared with patient self-reporting, screening was associated with the following factors: a higher percentage of stage T1 tumors (75.0% vs 17.1%, P = 0.109 in 1995–2000; 66.7% vs 40.4%, P < 0.001 in 2010; 67.8% vs 35.7%, P < 0.001 in 2015); a higher percentage of tumors with stage N0 lymph node status (67.3% vs. 48.4%, P = 0.007 in 2010); and a higher percentage of histologic grade I tumors (22.9% vs 13.9%, P = 0.017 in 2010). Conclusion Screen-detected breast cancer was associated with a greater number of favorable pathological characteristics. However, although screening had a beneficial role in early detection in China, we found fewer patients were detected by screening in this study compared with those in Western and Asian developed countries.

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Radio-induced Breast Cancers Display Aggressive Pathological Characteristics: A Retrospective Study by The French Pediatric Oncology Society (SFCE)

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2011.06.1946 ◽

2011 ◽

Vol 81 (2) ◽

pp. S664

Author(s):

C. Demoor-Goldschmidt ◽

F. De Vathaire ◽

O. Oberlin ◽

G. Noel ◽

V. Brillaud ◽

...

Keyword(s):

Retrospective Study ◽

Pediatric Oncology ◽

Breast Cancers ◽

Pathological Characteristics

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The Pattern of Proline, Glutamic Acid, and Leucine-Rich Protein 1 Expression in Chinese Women with Primary Breast Cancer

The International Journal of Biological Markers ◽

10.5301/jbm.5000078 ◽

2014 ◽

Vol 29 (1) ◽

pp. e1-e7 ◽

Cited By ~ 1

Author(s):

Yanzhi Zhang ◽

Peng Wang ◽

Mumu Shi ◽

Hironobu Sasano ◽

Monica S.M. Chan ◽

...

Keyword(s):

Breast Cancer ◽

Glutamic Acid ◽

Primary Breast Cancer ◽

Chinese Women ◽

Cancer Prognosis ◽

Clinicopathological Parameters ◽

Breast Cancers ◽

Breast Cancer Patients ◽

Ki 67 ◽

Her 2

Background Disparities of biomarkers’ expression in breast cancer across different races and ethnicities have been well documented. Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a novel ER coregulator, has been considered as a promising biomarker of breast cancer prognosis; however, the pattern of PELP1 expression in Chinese women with breast cancer has never been investigated. This study aims to provide useful reference on possible racial or ethnic differences of PELP1 expression in breast cancer by exploring the pattern of PELP1 expression in Chinese women with primary breast cancer. Methods The expression of PELP1 in primary breast cancer samples from 130 Chinese female patients was detected by immunohistochemistry and correlated to other clinicopathological parameters; for comparison, the expression of PELP1 in 26 benign breast fibroadenomas was also examined. Results The overall value of the PELP1 H-score in breast cancer was significantly higher than that in breast fibroadenoma (p<0.001). In our breast cancer patients, the ER/HER-2-positive group had significantly higher PELP1 H-scores than their negative counterparts (p=0.003 for ER and p=0.022 for HER-2); the Ki-67-high group also showed significantly higher PELP1 H-scores than the Ki-67-low group (p=0.008). No significant association between PELP1 H-scores and other clinicopathological parameters was found. Finally, the PELP1 H-score in breast cancers of the luminal B subtype was significantly higher than that in the triple negative subtype (p=0.002). Conclusion Overexpression of PELP1 in Chinese women with primary breast cancer appears to be associated with biomarkers of poor outcome; these results are similar to other reports based on Western populations.

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