Fecal microbiota transplantation research output from 2004 to 2017: a bibliometric analysis

Background: Fecal microbiota transplantation (FMT) is an emerging therapy against Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD). Although the therapy has gained prominence, there has been no bibliometric analysis of FMT. Methods: Studies published from 2004 to 2017 were extracted from the Science Citation Index Expanded. Bibliometric analysis were used to evaluate the number or cooperation of publications, countries, citations, references, journals, authors, institutions and keywords. Results: A total of 796 items were included, showing an increasing trend annually. Publications mainly came from 10 countries, led by the US (n = 363). In the top 100 articles ranked by the number of citations (range 47-1158), American Journal of Gastroenterology (2017 IF = 10.231) took the top spot. The co-citation network had 7 co-citation clusters headed by ‘recurrent Clostridium difficile infection’. The top 7 keywords with the strongest citation bursts had three parts, ‘microbiota’, ‘ diarrhea ’, and ‘case series’. All keywords were divided into four domains, ‘disease’, ‘nosogenesis’, ‘trial’, and ‘therapy’. Conclusions: This study shows the research performance of FMT from 2004 to 2017 and helps investigators master the trend of FMT, which is also an ongoing hotspot of research.

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Fecal microbiota transplantation research output from 2004 to 2017: a bibliometric analysis

PeerJ ◽

10.7717/peerj.6411 ◽

2019 ◽

Vol 7 ◽

pp. e6411 ◽

Cited By ~ 2

Author(s):

Yan Li ◽

Ziyuan Zou ◽

Xiaohui Bian ◽

Yushan Huang ◽

Yanru Wang ◽

...

Keyword(s):

Clostridium Difficile ◽

Bibliometric Analysis ◽

Fecal Microbiota Transplantation ◽

Research Output ◽

Research Performance ◽

Case Series ◽

Citation Network ◽

Fecal Microbiota ◽

Cooperation Network ◽

Number Of Citations

Background Fecal microbiota transplantation (FMT) is an emerging therapy against Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD). Although the therapy has gained prominence, there has been no bibliometric analysis of FMT. Methods Studies published from 2004 to 2017 were extracted from the Science Citation Index Expanded. Bibliometric analysis was used to evaluate the number or cooperation network of publications, countries, citations, references, journals, authors, institutions and keywords. Results A total of 796 items were included, showing an increasing trend annually. Publications mainly came from 10 countries, led by the US (n = 363). In the top 100 articles ranked by the number of citations (range 47–1,158), American Journal of Gastroenterology (2017 IF = 10.231) took the top spot. The co-citation network had 7 co-citation clusters headed by ‘recurrent Clostridium difficile infection’. The top 7 keywords with the strongest citation bursts had three parts, ‘microbiota’, ‘ diarrhea ’, and ‘case series’. All keywords were divided into four domains, ‘disease’, ‘nosogenesis’, ‘trial’, and ‘therapy’. Conclusions This study shows the research performance of FMT from 2004 to 2017 and helps investigators master the trend of FMT, which is also an ongoing hotspot of research.

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Peer Review #1 of "Fecal microbiota transplantation research output from 2004 to 2017: a bibliometric analysis (v0.2)"

10.7287/peerj.6411v0.2/reviews/1 ◽

2019 ◽

Keyword(s):

Peer Review ◽

Bibliometric Analysis ◽

Fecal Microbiota Transplantation ◽

Research Output ◽

Fecal Microbiota

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Transfer of Viral Communities between Human Individuals during Fecal Microbiota Transplantation

mBio ◽

10.1128/mbio.00322-16 ◽

2016 ◽

Vol 7 (2) ◽

Cited By ~ 52

Author(s):

Christel Chehoud ◽

Anatoly Dryga ◽

Young Hwang ◽

Dorottya Nagy-Szakal ◽

Emily B. Hollister ◽

...

Keyword(s):

Clostridium Difficile ◽

Fecal Microbiota Transplantation ◽

Case Series ◽

Fecal Microbiota ◽

Temperate Phage ◽

Human Cells ◽

Animal Cells ◽

Healthy Human ◽

Human Donor ◽

Viral Communities

ABSTRACT Fecal microbiota transplantation (FMT) is a highly effective treatment for refractory Clostridium difficile infections. However, concerns persist about unwanted cotransfer of pathogenic microbes such as viruses. Here we studed FMT from a single healthy human donor to three pediatric ulcerative colitis patients, each of whom received a course of 22 to 30 FMT treatments. Viral particles were purified from donor and recipient stool samples and sequenced; the reads were then assembled into contigs corresponding to viral genomes or partial genomes. Transfer of selected viruses was confirmed by quantitative PCR. Viral contigs present in the donor could be readily detected in recipients, with up to 32 different donor viral contigs appearing in a recipient sample. Reassuringly, none of these were viruses are known to replicate on human cells. Instead, viral contigs either scored as bacteriophage or could not be attributed taxonomically, suggestive of unstudied phage. The two most frequently transferred gene types were associated with temperate-phage replication. In addition, members of Siphoviridae , the group of typically temperate phages that includes phage lambda, were found to be transferred with significantly greater efficiency than other groups. On the basis of these findings, we propose that the temperate-phage replication style may promote efficient phage transfer between human individuals. In summary, we documented transfer of multiple viral lineages between human individuals through FMT, but in this case series, none were from viral groups known to infect human cells. IMPORTANCE Transfer of whole communities of viruses between humans has rarely been studied but is of likely medical importance. Here we studied fecal microbiota transplantation (FMT), a highly successful treatment for relapsing Clostridium difficile infection and, potentially, other gastrointestinal (GI) diseases. We investigated the transfer of viral communities during FMT and documented transfer of multiple viral lineages between humans. None of these were viruses that replicated on animal cells or that are known to be pathogenic. We found that temperate bacteriophage, which form stable associations with their hosts, were significantly more likely to be transferred during FMT. This supports a model in which the viral temperate replication style may have evolved in part to support efficient viral transmission between environments.

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Current challenges in the treatment of severe Clostridium difficile infection: early treatment potential of fecal microbiota transplantation

Therapeutic Advances in Gastroenterology ◽

10.1177/1756283x17690480 ◽

2017 ◽

Vol 10 (4) ◽

pp. 373-381 ◽

Cited By ~ 21

Author(s):

Yvette H. van Beurden ◽

Max Nieuwdorp ◽

Pablo J. E. J. van de Berg ◽

Chris J. J. Mulder ◽

Abraham Goorhuis

Keyword(s):

Clostridium Difficile ◽

Antibiotic Treatment ◽

Clostridium Difficile Infection ◽

Fecal Microbiota Transplantation ◽

Case Reports ◽

Case Series ◽

Fecal Microbiota ◽

Curative Treatment ◽

Bowel Surgery ◽

Recurrent Clostridium Difficile Infection

Fecal microbiota transplantation (FMT) is a very effective treatment for recurrent Clostridium difficile infection (CDI). Less is known about the application of FMT as a curative treatment of severe or complicated CDI. In this review, we present and discuss evidence supporting the curative use of FMT in severe or complicated CDI. We performed a literature search in PubMed and Embase for studies on the curative use of FMT in severe or complicated CDI. In addition, we describe a patient with severe CDI not responding to initial antibiotic treatment, who was successfully treated with curative FMT. We found 23 reports (12 case reports; 11 case series) about FMT as treatment for severe or complicated CDI. The patients described all had severe or complicated CDI, did not respond to conventional CDI antibiotic treatment and received FMT as last resort treatment. Patients were treated with (sequential) FMT, whether or not followed by additional antibiotic treatment for CDI. FMT, with or without additional antibiotic CDI treatment, appears to be a promising curative treatment option in patients with severe and complicated CDI, or only complicated CDI, who do not respond sufficiently to conventional antibiotic treatment. Treatment with FMT should be considered in these patients before proceeding to emergency bowel surgery.

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