Joseph Altman and Adult Neurogenesis: The Dogma of ‘‘No New Neurons’’ in the Adult Mammalian Brain

2009 ◽  
Keyword(s):  
Adult Neurogenesis ◽  
Mammalian Brain ◽  
Adult Mammalian Brain

scholarly journals Neurogenesis-mediated forgetting of complex paired-associates memories

2021 ◽  
Author(s):  
Jonathan R Epp ◽  
Leigh CP Botly ◽  
Sheena Josselyn ◽  
Paul W Frankland
Keyword(s):  
Adult Neurogenesis ◽  
Voluntary Exercise ◽  
Mammalian Brain ◽  
Reversal Task ◽  
Paired Associates ◽  
Location Task ◽  
The Stability ◽  
Adult Mammalian Brain ◽  
Critical Structure

The hippocampus is a critical structure involved in many forms of learning and memory. It is also one of the only regions in the adult mammalian brain that continues to generate new neurons throughout adulthood. This process of adult neurogenesis may increase the plasticity of the hippocampus which could be beneficial for learning but has also been demonstrated to decrease the stability of previously acquired memories. Here we test whether increased production of new neurons following the formation of a gradually acquired paired-associates task will result in forgetting of this type of memory. We trained mice in a touchscreen-based object/location task and then increased neurogenesis using voluntary exercise. Our results indicate that mice with increased neurogenesis show poor recall of the previously established memory. When subsequently exposed to a reversal task we also show that mice with increased neurogenesis require fewer correction trials to acquire the new task contingencies. This suggests that prior forgetting reduces perseveration on the now outdated memory. Together our results add to a growing body of literature which indicates the important role of adult neurogenesis in destabilizing previously acquired memories to allow for flexible encoding of new memories.

scholarly journals Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53

2009 ◽  
Vol 30 (3) ◽  
pp. 483-497 ◽  
Author(s):  
Silvia Medrano ◽  
Melissa Burns-Cusato ◽  
Marybless B. Atienza ◽  
Donya Rahimi ◽  
Heidi Scrable
Keyword(s):  
Mammalian Brain ◽  
Regenerative Capacity ◽  
Neural Precursors ◽  
Adult Mammalian Brain

scholarly journals Mercury Toxicity and Neurogenesis in the Mammalian Brain

2021 ◽  
Vol 22 (14) ◽  
pp. 7520
Author(s):  
Louise C. Abbott ◽  
Fikru Nigussie
Keyword(s):  
Neural Networks ◽  
Progenitor Cells ◽  
Adult Neurogenesis ◽  
Neural Progenitor Cells ◽  
Mammalian Brain ◽  
Mercury Toxicity ◽  
Embryonic Neurogenesis ◽  
Programmed Death ◽  
Final Integration ◽  
Developing Neurons

The mammalian brain is formed from billions of cells that include a wide array of neuronal and glial subtypes. Neural progenitor cells give rise to the vast majority of these cells during embryonic, fetal, and early postnatal developmental periods. The process of embryonic neurogenesis includes proliferation, differentiation, migration, the programmed death of some newly formed cells, and the final integration of differentiated neurons into neural networks. Adult neurogenesis also occurs in the mammalian brain, but adult neurogenesis is beyond the scope of this review. Developing embryonic neurons are particularly susceptible to neurotoxicants and especially mercury toxicity. This review focused on observations concerning how mercury, and in particular, methylmercury, affects neurogenesis in the developing mammalian brain. We summarized information on models used to study developmental mercury toxicity, theories of pathogenesis, and treatments that could be used to reduce the toxic effects of mercury on developing neurons.

Applying Basic Neuroscience to Aphasia Therapy

1995 ◽  
Vol 4 (4) ◽  
pp. 88-93 ◽  
Author(s):  
Kristen A. Keefe
Keyword(s):  
Learning And Memory ◽  
Neural Plasticity ◽  
Behavioral Interventions ◽  
Cortical Reorganization ◽  
Mammalian Brain ◽  
Cortical Injury ◽  
Aphasia Therapy ◽  
Neural Processes ◽  
Adult Mammalian Brain ◽  
Environmental Demands

Advances in basic neuroscience have increased our knowledge about the neural processes underlying learning and memory and the cortical reorganization that occurs in response to environmental demands and cortical injury. This article provides a selective review of published studies conducted in animals that examine functional and structural substrates of neural plasticity in the adult mammalian brain, and discusses the implications of this knowledge for aphasia therapy. The processes and constraints identified in the studies reviewed can be used to refine and justify current aphasia therapies, as well as to design additional behavioral interventions.

Adult Neurogenesis in the Mammalian Brain

2002 ◽  
pp. 779-798
Author(s):  
Patima Tanapat ◽  
Nicholas B. Hastings ◽  
Elizabeth Gould
Keyword(s):  
Adult Neurogenesis ◽  
Mammalian Brain
Sign in / Sign up

Export Citation Format

Share Document