Cannabinoids and Epilepsy

2017 ◽  
Author(s):  
Linda A. Parker
Keyword(s):  
Clinical Trials ◽  
Animal Models ◽  
Controlled Clinical Trials ◽  
Preclinical Research ◽  
Signalling System ◽  
Drug Of Choice ◽  
Relative Activation ◽  
Childhood Form ◽  
Gaba Transmission

Cannabis has historically been drug of choice in treating epilepsy, particularly in the 1800’s. However, there have been no modern controlled clinical trials on the effectiveness of cannabis or THC in treating seizures in humans. Preclinical research suggests that CB1 agonists reduce seizures in animal models, however, there is also some evidence that THC may be proconvulsant. It is now known epilepsy can substantially modify the endocannabinoid signalling system, by modifying the relative activation of excitatory glutamate and inhibitory GABA transmission. Considerable recent media interest has focussed on the potential of CBD to reduce seizures in a childhood form of epilepsy called Dravet’s syndrome. The evidence for the anti-convulsant potential of CBD and other cannabinoids is reviewed in this chapter.

scholarly journals Improving preclinical studies through replications

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Natascha Ingrid Drude ◽  
Lorena Martinez Gamboa ◽  
Meggie Danziger ◽  
Ulrich Dirnagl ◽  
Ulf Toelch
Keyword(s):  
Clinical Trials ◽  
Animal Models ◽  
Large Scale ◽  
Preclinical Studies ◽  
Efficient Allocation ◽  
Allocation Of Resources ◽  
Preclinical Research ◽  
Replication Studies ◽  
Animal Models Of Disease ◽  
Models Of Disease

The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of clinical trials fail, even when preclinical studies have apparently demonstrated the efficacy of a given intervention. A number of large-scale replication studies are currently trying to identify the factors that influence the robustness of preclinical research. Here, we discuss replications in the context of preclinical research trajectories, and argue that increasing validity should be a priority when selecting experiments to replicate and when performing the replication. We conclude that systematically improving three domains of validity – internal, external and translational – will result in a more efficient allocation of resources, will be more ethical, and will ultimately increase the chances of successful translation.

A rejoinder to "Psychotherapy research ethics: Continuing the debate on controlled clinical trials."

1987 ◽  
Vol 42 (12) ◽  
pp. 1132-1133
Author(s):  
Stanley D. Imber ◽  
Lawrence M. Glanz ◽  
Irene Elkin ◽  
Stuart M. Sotsky ◽  
Jenny L. Boyer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Research Ethics ◽  
Psychotherapy Research ◽  
Controlled Clinical Trials

A Multivariate Approach to Analyze Ordinal Data Collected in Clinical Trials of Analgesic Agents

1979 ◽  
Vol 18 (03) ◽  
pp. 175-179
Author(s):  
E. Mabubini ◽  
M. Rainisio ◽  
V. Mandelli
Keyword(s):  
Clinical Trials ◽  
Multivariate Analysis ◽  
Analgesic Effect ◽  
Ordinal Data ◽  
Ordinal Scale ◽  
Multivariate Approach ◽  
Controlled Clinical Trials ◽  
Second Stage ◽  
Analgesic Agents ◽  
Relevant Factors

After pointing out the drawbacks of the approach commonly used to analyze the data collected in controlled clinical trials carried out to evaluate the analgesic effect of potential agents, the authors suggest a procedure suitable for analyzing data coded according to an ordinal scale. In the first stage a multivariate analysis is carried out on the codec! data and the projection of each result in the space of the most relevant factors is obtained. In the second stage the whole set of these values is processed by distribution-free tests. The procedure has been applied to data previously published by VENTAITBIDDA et al. [18].

Fluoxetine Not Associated With Increased Violence or Aggression in Controlled Clinical Trials

1992 ◽  
Vol 4 (4) ◽  
pp. 285-295 ◽  
Author(s):  
John Heiligenstein ◽  
Emil Coccaro ◽  
Janet Potvin ◽  
Charles Beasley ◽  
Bruce Dornseif ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Controlled Clinical Trials
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