scholarly journals Correction: Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Janelle MP Pakan ◽  
Scott C Lowe ◽  
Evelyn Dylda ◽  
Sander W Keemink ◽  
Stephen P Currie ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Behavioral State ◽  
Cell Type ◽  
Cell Type Specific ◽  
Context Dependent ◽  
Mouse Visual Cortex

scholarly journals Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Janelle MP Pakan ◽  
Scott C Lowe ◽  
Evelyn Dylda ◽  
Sander W Keemink ◽  
Stephen P Currie ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Pyramidal Neurons ◽  
Visual Stimulation ◽  
Inhibitory Neurons ◽  
Behavioral State ◽  
Visual Responses ◽  
Cell Type ◽  
Sensory Stimuli ◽  
Context Dependent

Cortical responses to sensory stimuli are modulated by behavioral state. In the primary visual cortex (V1), visual responses of pyramidal neurons increase during locomotion. This response gain was suggested to be mediated through inhibitory neurons, resulting in the disinhibition of pyramidal neurons. Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model. In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive. Context-dependent locomotion responses were found in each cell type, with the highest proportion among SST neurons. These findings establish that modulation of neuronal activity by locomotion is context-dependent and contest the generality of a disinhibitory circuit for gain control of sensory responses by behavioral state.

scholarly journals Cell Type-Specific, Presynaptic LTP of Inhibitory Synapses on Fast-Spiking GABAergic Neurons in the Mouse Visual Cortex

2012 ◽  
Vol 32 (38) ◽  
pp. 13189-13199 ◽  
Author(s):  
A. Sarihi ◽  
J. Mirnajafi-Zadeh ◽  
B. Jiang ◽  
K. Sohya ◽  
M.-S. Safari ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Gabaergic Neurons ◽  
Inhibitory Synapses ◽  
Cell Type ◽  
Cell Type Specific ◽  
Fast Spiking ◽  
Mouse Visual Cortex

scholarly journals Cell type‐specific nuclear pores: a case in point for context‐dependent stoichiometry of molecular machines

2013 ◽  
Vol 9 (1) ◽  
pp. 648 ◽  
Author(s):  
Alessandro Ori ◽  
Niccolò Banterle ◽  
Murat Iskar ◽  
Amparo Andrés‐Pons ◽  
Claudia Escher ◽  
...  
Keyword(s):  
Molecular Machines ◽  
Cell Type ◽  
Nuclear Pores ◽  
Cell Type Specific ◽  
Context Dependent

scholarly journals Modulation of Visual Responses by Behavioral State in Mouse Visual Cortex

Neuron ◽  
2010 ◽  
Vol 65 (4) ◽  
pp. 472-479 ◽  
Author(s):  
Cristopher M. Niell ◽  
Michael P. Stryker
Keyword(s):  
Visual Cortex ◽  
Behavioral State ◽  
Visual Responses ◽  
Mouse Visual Cortex

scholarly journals RNA polymerase II pausing as a context-dependent reader of the genome

2016 ◽  
Vol 94 (1) ◽  
pp. 82-92 ◽  
Author(s):  
Adam Scheidegger ◽  
Sergei Nechaev
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Cell Types ◽  
Gene Promoters ◽  
Cell Type ◽  
Pol Ii ◽  
Cell Type Specific ◽  
Pol Ii Pausing ◽  
Context Dependent ◽  
Specific Regulation

The RNA polymerase II (Pol II) transcribes all mRNA genes in eukaryotes and is among the most highly regulated enzymes in the cell. The classic model of mRNA gene regulation involves recruitment of the RNA polymerase to gene promoters in response to environmental signals. Higher eukaryotes have an additional ability to generate multiple cell types. This extra level of regulation enables each cell to interpret the same genome by committing to one of the many possible transcription programs and executing it in a precise and robust manner. Whereas multiple mechanisms are implicated in cell type-specific transcriptional regulation, how one genome can give rise to distinct transcriptional programs and what mechanisms activate and maintain the appropriate program in each cell remains unclear. This review focuses on the process of promoter-proximal Pol II pausing during early transcription elongation as a key step in context-dependent interpretation of the metazoan genome. We highlight aspects of promoter-proximal Pol II pausing, including its interplay with epigenetic mechanisms, that may enable cell type-specific regulation, and emphasize some of the pertinent questions that remain unanswered and open for investigation.

scholarly journals Cell-Type-Specific Thalamocortical Inputs Constrain Direction Map Formation in Visual Cortex

Cell Reports ◽  
2019 ◽  
Vol 26 (5) ◽  
pp. 1082-1088.e3
Author(s):  
Megumi Nishiyama ◽  
Teppei Matsui ◽  
Tomonari Murakami ◽  
Kenta M. Hagihara ◽  
Kenichi Ohki
Keyword(s):  
Visual Cortex ◽  
Cell Type ◽  
Cell Type Specific
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