scholarly journals Author response: Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

2020 ◽  
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Amin Haghani ◽  
Mafalda Cacciottolo ◽  
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Max Thorwald ◽  
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2020 ◽  
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Kota Tamada ◽  
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2020 ◽  
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Rita De Gasperi ◽  
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2018 ◽  
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Diptendu Mukherjee ◽  
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Eyal Itskovits ◽  
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...  
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2017 ◽  
Vol 24 (1) ◽  
pp. 75-87 ◽  
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Kishore Kanakabandi ◽  
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2005 ◽  
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Tao Ju ◽  
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2010 ◽  
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pp. 12698-12703 ◽  
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Jeremy A. Miller ◽  
Steve Horvath ◽  
Daniel H. Geschwind

2000 ◽  
Vol 10 (12) ◽  
pp. 2006-2021 ◽  
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Hamish S. Scott ◽  
Marie Pierre Papasavvas ◽  
Colette Rossier ◽  
Emmanuel S. Antonarakis ◽  
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Trisomy 21, or Down syndrome (DS), is the most common genetic cause of mental retardation. Changes in the neuropathology, neurochemistry, neurophysiology, and neuropharmacology of DS patients' brains indicate that there is probably abnormal development and maintenance of central nervous system structure and function. The segmental trisomy mouse (Ts65Dn) is a model of DS that shows analogous neurobehavioral defects. We have studied the global gene expression profiles of normal and Ts65Dn male and normal female mice brains (P30) using the serial analysis of gene expression (SAGE) technique. From the combined sample we collected a total of 152,791 RNA tags and observed 45,856 unique tags in the mouse brain transcriptome. There are 14 ribosomal protein genes (nine underexpressed) among the 330 statistically significant differences between normal male and Ts65Dn male brains, which possibly implies abnormal ribosomal biogenesis in the development and maintenance of DS phenotypes. This study contributes to the establishment of a mouse brain transcriptome and provides the first overall analysis of the differences in gene expression in aneuploid versus normal mammalian brain cells.


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