scholarly journals Author response: Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

2020 ◽  
Author(s):  
Giulia LM Boezio ◽  
Anabela Bensimon-Brito ◽  
Janett Piesker ◽  
Stefan Guenther ◽  
Christian SM Helker ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Development ◽  
Outflow Tract ◽  
Author Response ◽  
Cardiac Outflow

scholarly journals Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Giulia LM Boezio ◽  
Anabela Bensimon-Brito ◽  
Janett Piesker ◽  
Stefan Guenther ◽  
Christian SM Helker ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Outflow Tract ◽  
Aortic Aneurysms ◽  
Β Receptor ◽  
And Function ◽  
Cardiac Outflow

The development of the cardiac outflow tract (OFT), which connects the heart to the great arteries, relies on a complex crosstalk between endothelial (ECs) and smooth muscle (SMCs) cells. Defects in OFT development can lead to severe malformations, including aortic aneurysms, which are frequently associated with impaired TGF-β signaling. To better understand the role of TGF-β signaling in OFT formation, we generated zebrafish lacking the TGF-β receptor Alk5 and found a strikingly specific dilation of the OFT: alk5-/- OFTs exhibit increased EC numbers as well as extracellular matrix (ECM) and SMC disorganization. Surprisingly, endothelial-specific alk5 overexpression in alk5-/- rescues the EC, ECM, and SMC defects. Transcriptomic analyses reveal downregulation of the ECM gene fibulin-5, which when overexpressed in ECs ameliorates OFT morphology and function. These findings reveal a new requirement for endothelial TGF-β signaling in OFT morphogenesis and suggest an important role for the endothelium in the etiology of aortic malformations.

scholarly journals Author response: Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

2018 ◽  
Author(s):  
Simon Bulley ◽  
Carlos Fernández-Peña ◽  
Raquibul Hasan ◽  
M Dennis Leo ◽  
Padmapriya Muralidharan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Systemic Blood Pressure ◽  
Author Response ◽  
Arterial Smooth Muscle Cell ◽  
Systemic Blood ◽  
Arterial Smooth Muscle

scholarly journals Author response: Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

2018 ◽  
Author(s):  
Simon Bulley ◽  
Carlos Fernández-Peña ◽  
Raquibul Hasan ◽  
M Dennis Leo ◽  
Padmapriya Muralidharan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Systemic Blood Pressure ◽  
Author Response ◽  
Arterial Smooth Muscle Cell ◽  
Systemic Blood ◽  
Arterial Smooth Muscle
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