Effects of 37˚C Carbon Dioxide Pneumoperitoneum on Core Body Temperature, Systolic Blood Pressure, Heart Rate and Acid-Base Balance: A Randomized Double-blind Controlled Trial

This work presents the effects of multimodal anesthesia with neuraxial blockade on the basic parameters of central hemodynamics in patients operated for lung tumors, revealed by method of terapolar rheovasography by Kubicek (systolic blood pressure, diastolic, average heart rate, ejection fraction, minute volume of blood circulation, cardiac index, oxygen delivery index, the index of the total peripheral vascular resistance), as well the effects on acid‐base balance of arterial blood in the immediate post‐operative period. The level of antinociceptive protection was assessed by visual analogue scale. Comparison of results of patients operated by means of multimodal anesthesia and the patients, operated in an inhalation intravenous anesthesia with artificial lung ventilation and peri‐operative analgesia by opioid analgesics has revealed that the hemodynamic profile of the first group of patients is characterized by stability of the basic parameters such as blood pressure and heart rate, the lack of a pronounced reduction of the ejection fraction and stroke volume of the heart, despite vasoplegia caused by epidural blockade. The level of partial oxygen tension of arterial blood was decreased in the early postoperative period, but it was in the normal limits and he was statistically significantly higher than in the comparison group that can help reduce the risk of post‐operative complications. Significantly lower level of pain indicates adequate antinociceptive protection of patients.

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Roles of Renal Proximal Tubule Transport in Acid/Base Balance and Blood Pressure Regulation

BioMed Research International ◽

10.1155/2014/504808 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 9

Author(s):

Motonobu Nakamura ◽

Ayumi Shirai ◽

Osamu Yamazaki ◽

Nobuhiko Satoh ◽

Masashi Suzuki ◽

...

Keyword(s):

Blood Pressure ◽

Ang Ii ◽

Acid Base Balance ◽

Acid Base ◽

Blood Pressure Homeostasis ◽

Base Balance ◽

Proximal Renal Tubular Acidosis ◽

Renal Tubular ◽

Regulation Of Blood Pressure

Sodium-coupled bicarbonate absorption from renal proximal tubules (PTs) plays a pivotal role in the maintenance of systemic acid/base balance. Indeed, mutations in the Na+-HCO3-cotransporter NBCe1, which mediates a majority of bicarbonate exit from PTs, cause severe proximal renal tubular acidosis associated with ocular and other extrarenal abnormalities. Sodium transport in PTs also plays an important role in the regulation of blood pressure. For example, PT transport stimulation by insulin may be involved in the pathogenesis of hypertension associated with insulin resistance. Type 1 angiotensin (Ang) II receptors in PT are critical for blood pressure homeostasis. Paradoxically, the effects of Ang II on PT transport are known to be biphasic. Unlike in other species, however, Ang II is recently shown to dose-dependently stimulate human PT transport via nitric oxide/cGMP/ERK pathway, which may represent a novel therapeutic target in human hypertension. In this paper, we will review the physiological and pathophysiological roles of PT transport.

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Comparison between Hypertonic Saline 3% and Mannitol, the Most Commonly Used Osmotic Agents, Regarding Effect on Blood Pressure, Electrolytes Level and Acid Base Balance

The Medical Journal of Cairo University ◽

10.21608/mjcu.2018.55571 ◽

2018 ◽

Vol 86 (3) ◽

pp. 837-842

Author(s):

MOHAMMED H.E. HAFEZ, M.D.; GIHAN M. OBAYAH, M.D. ◽

MAHA M.I. YOUSSEF, M.D.; MOHAMMED S. MOHAMMED, M.D. ◽

OMNIA A. MANDOR, M.Sc.

Keyword(s):

Blood Pressure ◽

Hypertonic Saline ◽

Acid Base Balance ◽

Acid Base ◽

Base Balance ◽

Osmotic Agents

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Haemoglobin function in intact lamprey erythrocytes: interactions with membrane function in the regulation of gas transport and acid-base balance.

Journal of Experimental Biology ◽

10.1242/jeb.198.12.2423 ◽

1995 ◽

Vol 198 (12) ◽

pp. 2423-2430 ◽

Cited By ~ 2

Author(s):

M Nikinmaa ◽

S Airaksinen ◽

L V Virkki

Keyword(s):

Carbon Dioxide ◽

Gas Transport ◽

Oxygen Affinity ◽

Oxygen Binding ◽

Acid Base Balance ◽

Acid Base ◽

Red Cell Membrane ◽

Membrane Function ◽

Acid And Base ◽

Base Balance

Haemoglobin function within lamprey erythrocytes offers a unique solution to gas transport among vertebrates. Lamprey haemoglobin within intact erythrocytes is in oligomer/monomer equilibrium and has an oxygen affinity similar to that of haemoglobin in other active fishes. The cooperativity of oxygen binding, which is reduced at low pH values, the effect of protons and the effect of the concentration of haemoglobin on its oxygen affinity are all due to dissociation/association reactions of the haemoglobin molecules. The permeability of the lamprey red cell membrane to acid and base equivalents is very low, and plasma bicarbonate cannot therefore be dehydrated to carbon dioxide to any significant extent during the residence time of blood in the gills. This potential limitation on carbon dioxide excretion is overcome, however, by the high intraerythrocytic pH and the marked oxygenation-linked pH changes in the erythrocyte, which are due to the large Haldane effect of the haemoglobin. Owing to the relative impermeability of the erythrocyte membrane to acid equivalents, intraerythrocytic haemoglobin cannot take part in the acid-base buffering of the extracellular compartment. As a consequence, extracellular acid loads cause marked fluctuations in plasma pH.

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