Gorlın’s Syndrome wıth Aggressıve Basal Cell Carcınoma: A Case Report

2016 ◽  
Author(s):  
FT Demir ◽  
IK Altunay ◽  
H Yamac ◽  
O Yalcin
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Gorlin’S Syndrome ◽  
Gorlin's Syndrome

Multiple neoplasms following craniospinal irradiation for medulloblastoma in a patient with nevoid basal cell carcinoma syndrome

1997 ◽  
Vol 86 (2) ◽  
pp. 286-288 ◽  
Author(s):  
Sean O'Malley ◽  
David Weitman ◽  
Michael Olding ◽  
Laligam Sekhar
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Subsequent Development ◽  
Craniospinal Irradiation ◽  
Malignant Neoplasms ◽  
Content Type ◽  
Multiple Neoplasms ◽  
Gorlin’S Syndrome ◽  
Gorlin's Syndrome

✓ A 28-year-old man presented to the authors' hospital with multiple intracranial tumors. At 2 years of age, he had undergone resection of a medulloblastoma and received adjunctive craniospinal irradiation. Subsequently, he was diagnosed with nevoid basal cell carcinoma syndrome, Gorlin's syndrome. Since his first presentation, he has required surgery for multiple basal cell carcinomas, an osteochondroma of the rib, two meningiomas, a trigeminal schwannoma, and a pleomorphic liposarcoma, all of which arose within the radiation field. Despite this impressive list of benign and malignant neoplasms, the patient is relatively well and leads a normal life. The authors examine the relationships between Gorlin's syndrome and radiation therapy and the subsequent development of tumors.

Tumours of the skin

2020 ◽  
pp. 5732-5742
Author(s):  
Edel O’Toole
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Ultraviolet Light ◽  
Basal Cell ◽  
Light Exposure ◽  
Human Cancer ◽  
Skin Lesions ◽  
Gorlin’S Syndrome ◽  
Gorlin's Syndrome

A variety of tumours, both benign and malignant, are found in skin. Benign skin lesions, such as seborrhoeic keratoses and skin tags, are often just a cosmetic nuisance, but some benign skin lesions can be a component of diseases with serious medical consequences (e.g. neurofibromatosis or LEOPARD syndrome). Skin cancer is the most common human cancer and its incidence continues to increase. It most commonly affects older, fair-skinned individuals who have had either acute intermittent exposure to ultraviolet light or chronic ultraviolet light exposure. Organ transplant recipients have a 200-fold increased risk of squamous cell carcinoma. About 2% of patients who develop skin cancer have a genetic predisposition, for example, Gorlin’s syndrome in basal cell carcinoma and familial melanoma syndromes in malignant melanoma. Mutations in the PTCH gene cause Gorlin’s syndrome, and loss of heterozygosity at that locus is also present in most sporadic basal cell carcinoma.

Infected Palmar Pits: A Rare Presentation of Gorlin’s Syndrome

2005 ◽  
Vol 30 (5) ◽  
pp. 459-460
Author(s):  
R. NASSAB ◽  
S. RAYATT ◽  
F. PEART
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Autosomal Dominant ◽  
Rare Presentation ◽  
Gorlin’S Syndrome ◽  
Gorlin's Syndrome

This paper presents a rare hand presentation of Gorlin’s Syndrome, also known as Naevoid Basal Cell Carcinoma Syndrome, which has not been reported previously. This condition is an autosomal dominant, multisystem condition whose diagnosis is important to ensure further surveillance and treatment of features of the condition not routinely dealt with by hand surgeons. However, hand surgeons should be aware of this condition and those parts of the syndrome which may present to them.

NAEVOID BASAL CELL CARCINOMA (GORLIN'S) SYNDROME

1993 ◽  
Vol 63 (5) ◽  
pp. 413-415 ◽  
Author(s):  
Manu N. Mathur ◽  
John F. Thompson ◽  
Christopher J. O'Brien ◽  
Timothy I. Davidson ◽  
William H. McCarthy
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Gorlin’S Syndrome ◽  
Gorlin's Syndrome
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