scholarly journals Efficacy of Platelet-Rich Plasma in Reduction of Post-Operative Split-Thickness Skin Graft Loss and Hematoma Formation: A Meta-Analysis

Cureus ◽  
2021 ◽  
Author(s):  
Anshika Tyagi ◽  
Apurv Gupta ◽  
Vicente I Martires III ◽  
Moises Romo ◽  
Ishan Garg ◽  
...  
Keyword(s):  
Skin Graft ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Graft Loss ◽  
Split Thickness Skin Graft ◽  
Hematoma Formation ◽  
Thickness Skin

Biological versus non-biological dressings in the management of split-thickness skin-graft donor sites: a systematic review and meta-analysis

2020 ◽  
Vol 29 (10) ◽  
pp. 604-610
Author(s):  
Shafiq Rahman ◽  
Benjamin Langridge ◽  
Ahmed Al-Hadad ◽  
Rehman Ali Khan ◽  
Muhammad Hyder Junejo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Skin Graft ◽  
Meta Analysis ◽  
Healing Time ◽  
Conclusive Evidence ◽  
Split Thickness Skin Graft ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Thickness Skin

Objective: There are currently no definitive guidelines regarding the management of split-thickness skin-graft (STSG) donor sites. The literature reports biological and non-biological dressings as the two main groups; however, there is no conclusive evidence regarding the ideal type. A systematic review and meta-analysis of existing clinical trials was performed to compare biological and non-biological dressings in managing STSG donor sites. Method: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards was used to conduct this study. Electronic databases including MEDLINE, Embase, CINAHL and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched by two authors (SR and BL). Data analysis was performed with RevMan 5.3. Results: In total, 10 studies, consisting of eight randomised controlled trials and two observational assessments, were identified. Wound healing time was faster with biological dressings compared to non-biological dressings (mean difference -5.44 days; p<0.05). A higher epithelialisation rate was also noted for biological dressings. There was no difference in the infection rate between the two study groups (odds ratio [OR] 0.39; 95% confidence interval [CI] 0.15–1.04) or wound exudation (OR 0.31; 95% CI 0.01–8.28). The pain level experienced during dressing changes in both groups was reported to be similar. Conclusion: The rate of epithelialisation and wound healing is greater for STSG donor sites when treated with biological dressings, but they offer no difference in terms of reducing pain, limiting infection or exudation.

scholarly journals Reduction of pain via platelet-rich plasma in split-thickness skin graft donor sites: a series of matched pairs

2015 ◽  
Vol 6 (1) ◽  
pp. 24972 ◽  
Author(s):  
John D. Miller ◽  
Timothy M. Rankin ◽  
Natalie T. Hua ◽  
Tina Ontiveros ◽  
Nicholas A. Giovinco ◽  
...  
Keyword(s):  
Skin Graft ◽  
Platelet Rich Plasma ◽  
Split Thickness Skin Graft ◽  
Matched Pairs ◽  
Thickness Skin ◽  
Reduction Of Pain ◽  
Graft Donor

Platelet-rich plasma-containing fragmin-protamine micro-nanoparticles promote epithelialization and angiogenesis in split-thickness skin graft donor sites

2015 ◽  
Vol 193 (1) ◽  
pp. 483-491 ◽  
Author(s):  
Yuki Takabayashi ◽  
Masayuki Ishihara ◽  
Yuki Sumi ◽  
Makoto Takikawa ◽  
Shingo Nakamura ◽  
...  
Keyword(s):  
Skin Graft ◽  
Platelet Rich Plasma ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Graft Donor

scholarly journals Efficacy of autologous platelet rich plasma over conventional mechanical fixation methods in split thickness skin grafting

2018 ◽  
Vol 6 (1) ◽  
pp. 108 ◽  
Author(s):  
Girish Umashankar Thimmanahalli ◽  
Mahesh Kumar
Keyword(s):  
Skin Graft ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Split Thickness Skin Graft ◽  
Skin Defect ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Autologous Platelet Rich Plasma ◽  
Graft Reconstruction ◽  
Autologous Platelet

Background: Platelet-Rich Plasma (PRP) is an autologous product derived from whole blood through the process of gradient density centrifugation. After skin graft reconstruction, the healing process is longer and may be difficult, depending on the wound site, skin defect size, and patient comorbidities. The potential value of PRP lies in its ability to incorporate high concentrations of platelet-derived growth factors into the skin graft. Since not all patients afford commercially available recombinant platelet rich plasma for skin graft, platelet extract from patient’s own blood is being used in this study to test and demonstrate the therapeutic role of PRP in skin graft. The aim of this randomized, prospective study is to compare the effectiveness of PRP in skin graft with conventional method like sutures, staplers or glue.Methods: The source of data were the patients admitted as inpatients for the management of wounds to the department of general surgery, JSS Hospital, Mysore from September 2016 to September 2018. Total of 60 patients were studied; 30 cases were randomly chosen for study with autologous platelet rich plasma and 30 cases received conventional methods like staples/sutures used to anchor the skin grafts in a control group.Results: Autologous PRP showed faster and better healing rates. With PRP study group instant graft adherence was seen in all cases. Hematoma, graft edema, discharge from graft site, frequency of dressings and duration of stay in hospital were significantly less in the PRP. There were no adverse effects or reactions seen with the use of autologous PRP among the study group.Conclusions: The combination of PRP with Split Thickness Skin Graft (STSG) significantly improved clinical outcomes and shortened the wound healing time. Therefore, this treatment combination could provide a way to heal skin after skin graft reconstruction with minimal recovery time. It is found to be highly beneficial in many aspects both to the patient and surgeon based on our results.

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