scholarly journals The Effectiveness of Autologous Platelet Rich Plasma Application in the Wound Bed Prior to Resurfacing with Split Thickness Skin Graft vs. Conventional Mechanical Fixation Using Sutures and Staples

2019 ◽  
Vol 8 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Subha Dhua ◽  
Suhas T.R. ◽  
Balagangadhar Tilak ◽  
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...  
2018 ◽  
Vol 6 (1) ◽  
pp. 108 ◽  
Author(s):  
Girish Umashankar Thimmanahalli ◽  
Mahesh Kumar

Background: Platelet-Rich Plasma (PRP) is an autologous product derived from whole blood through the process of gradient density centrifugation. After skin graft reconstruction, the healing process is longer and may be difficult, depending on the wound site, skin defect size, and patient comorbidities. The potential value of PRP lies in its ability to incorporate high concentrations of platelet-derived growth factors into the skin graft. Since not all patients afford commercially available recombinant platelet rich plasma for skin graft, platelet extract from patient’s own blood is being used in this study to test and demonstrate the therapeutic role of PRP in skin graft. The aim of this randomized, prospective study is to compare the effectiveness of PRP in skin graft with conventional method like sutures, staplers or glue.Methods: The source of data were the patients admitted as inpatients for the management of wounds to the department of general surgery, JSS Hospital, Mysore from September 2016 to September 2018. Total of 60 patients were studied; 30 cases were randomly chosen for study with autologous platelet rich plasma and 30 cases received conventional methods like staples/sutures used to anchor the skin grafts in a control group.Results: Autologous PRP showed faster and better healing rates. With PRP study group instant graft adherence was seen in all cases. Hematoma, graft edema, discharge from graft site, frequency of dressings and duration of stay in hospital were significantly less in the PRP. There were no adverse effects or reactions seen with the use of autologous PRP among the study group.Conclusions: The combination of PRP with Split Thickness Skin Graft (STSG) significantly improved clinical outcomes and shortened the wound healing time. Therefore, this treatment combination could provide a way to heal skin after skin graft reconstruction with minimal recovery time. It is found to be highly beneficial in many aspects both to the patient and surgeon based on our results.


2021 ◽  
pp. 1-4
Author(s):  
Ankur Deshwali ◽  
Peeyush Kesharwani ◽  
Rohan Gupta

TITLE Efficacy of autologous platelet rich plasma over conventional mechanical fixation methods in split thickness skin grafting . AIMS AND OBJECTIVES to determine the efficacy of autologous platelet rich plasma over conventional mechanical fixation methods in split thickness skin grafting. METHODS  This a prospective randomized controlled study, conducted in the Department of surgery, SAIMS Medical College and P.G Institute, Indore for a period of two years from September 2016 to September 2018. A total of 20 patients were included in the study, and divided into two groups of 10 each randomly. The study was approved by the local ethical committee of our hospital. An informed written consent was obtained from all patients.  Total of 20 patients were studied; 10 cases were randomly chosen for study with autologous platelet rich plasma and 10 cases received conventional methods like staples/sutures used to anchor the skin grafts in a control group. RESULTS Autologous PRP showed faster and better healing rates. With PRP study group instant graft adherence was seen in all cases. Hematoma, graft edema, discharge from graft site, frequency of dressings and duration of stay in hospital were significantly less in the PRP. There were no adverse effects or reactions seen with the use of autologous PRP among the study group. CONCLUSION  The combination of PRP with Split Thickness Skin Graft (STSG) significantly improved clinical outcomes and shortened the wound healing time. Therefore, this treatment combination could provide a way to heal skin after skin graft reconstruction with minimal recovery time. It is found to be highly beneficial in many aspects both to the patient and surgeon based on our results.


2006 ◽  
Vol 96 (2) ◽  
pp. 139-147
Author(s):  
Thomas S. Roukis ◽  
Jeffrey R. Baker ◽  
Breck Tiernan

We describe a 70-year-old nonimmunocompromised woman with spontaneous bilateral ankle and midfoot sepsis and a deep-space abscess of the right lower leg. Salvage of both limbs was achieved by aggressive bilateral soft-tissue and osseous debridement, including a four-compartment fasciotomy of the right lower leg, antibiotic-loaded polymethyl methacrylate bone cement implantation, delayed allogeneic bone grafting of the osseous defects impregnated with autologous platelet-rich plasma bilaterally, and external fixation immobilization, implantable bone growth stimulation, and split-thickness skin graft coverage of the right lower leg, ankle, and foot. Osseous incorporation of the bone grafts bilaterally occurred 8 weeks after surgery. No soft-tissue or osseous complications occurred during the postoperative period or at 18-month follow-up except for arthrofibrosis in the right ankle; there was no evidence of recurrent abscesses, sequestrum, or wound-related problems. A review of the literature regarding bilateral pedal sepsis and the techniques used for limb salvage in this patient are presented in detail. (J Am Podiatr Med Assoc 96(2): 139–147, 2006)


2015 ◽  
Vol 6 (1) ◽  
pp. 24972 ◽  
Author(s):  
John D. Miller ◽  
Timothy M. Rankin ◽  
Natalie T. Hua ◽  
Tina Ontiveros ◽  
Nicholas A. Giovinco ◽  
...  

2015 ◽  
Vol 193 (1) ◽  
pp. 483-491 ◽  
Author(s):  
Yuki Takabayashi ◽  
Masayuki Ishihara ◽  
Yuki Sumi ◽  
Makoto Takikawa ◽  
Shingo Nakamura ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Yuan-Sheng Tzeng ◽  
Shou-Cheng Deng ◽  
Chih-Hsing Wang ◽  
Jui-Che Tsai ◽  
Tim-Mo Chen ◽  
...  

Lower extremity ulcers in diabetic patients are difficult to treat. Recently, the use of human blood platelet-derived components in this indication has been raising interest. In this study, we have evaluated the safety and efficacy of the combination of autologous platelet gel (PG) and skin graft for treating large size recalcitrant ulcers. Eight consecutive diabetic patients aged 25 to 82 with nine nonhealing lower extremity ulcers (median size of 50 cm2; range 15–150 cm2) were treated. Skin ulcer was debrided, and the wound was sprayed after 7 to 10 days with autologous platelet-rich plasma and thrombin. Thin split-thickness skin graft with multiple slits was then applied on the wound bed and fixed with staples or cat-gut sutures. There were no adverse reactions observed during the study. Eight out of 9 skin grafts took well. The interval between skin graft and complete wound healing ranged from 2 to 3 weeks in the 8 successful cases. No ulcer recurrence was noted in those patients during the follow-up period of 2 to 19 months. In this study, the combination of autologous platelet gel and skin grafting has proven beneficial to heal large-size recalcitrant ulcers.


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