This case report describes two more patients with the unusual side effect of spinal morphine-induced hypothermia. This side effect is more accurately defined as a syndrome consisting of hypothermia that is profound, refractory, and delayed in onset with paradoxical signs and symptoms, and psychological effects. The two cases presented here and previously published reports show a significant correlation not only with short stature [<163cm] and advancing [age>28] maternal age, but also female gender, pregnancy, and Caesarean section. Older, shorter patients undergoing C-section may require more careful selection and monitoring if intrathecal morphine is employed for postoperative pain relief.
Possible Aripiprazole-Induced Hypothermia: An “Icy” Side Effect?
