Anti-inflammatory Effects of Water Extract of Eucommia ulmoides OLIVER on the LPS-induced RAW 264.7 Cells

2012 ◽  
Vol 20 (5) ◽  
pp. 381-386 ◽  
Author(s):  
Young-Ock Kim ◽  
Sang-Won Lee ◽  
Sang-Hyun Sohn ◽  
Seung-Yu Kim ◽  
Myung-Sook Oh ◽  
...  
2019 ◽  
Vol 36 (4) ◽  
pp. 256-263
Author(s):  
Hwa Yeon Ryu ◽  
Hyun Lee ◽  
Hae Jin Kong ◽  
Jae Hui Kang

2014 ◽  
Vol 42 (04) ◽  
pp. 891-904 ◽  
Author(s):  
Mi Young Song ◽  
Hyo Won Jung ◽  
Seok Yong Kang ◽  
Kyung-Ho Kim ◽  
Yong-Ki Park

The root bark of Lycium barbarum (Lycii radicis cortex, LRC) is used as a cooling agent for fever and night sweats in East Asian traditional medicine. The inhibitory effect of LRC water extract on inflammation is unknown. In this study, the anti-inflammatory effect of LRC was investigated in lipopolysaccharide (LPS)-stimulated mouse macrophage, RAW 264.7 cells. LRC extract significantly decreased the LPS-induced production of inflammatory mediators, nitric oxide (NO), prostaglandin (PG) E2 and pro-inflammatory cytokines, interleukin (IL)-1β and IL-6 in the cells. In addition, LRC extract inhibited the LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA and protein, and inflammatory cytokines mRNA in the cells. The action mechanism of LRC underlies the blocking of LPS-mediated p38 and Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPKs), and the nuclear factor (NF)-κB signaling pathway. These results indicate that LRC extract inhibits the inflammatory response in activated macrophages by down-regulating the transcription levels of inflammatory mediators and blocking the MAPKs and NF-κB pathway.


2016 ◽  
Vol 24 (3) ◽  
pp. 228-236 ◽  
Author(s):  
Ji Hun Jang ◽  
◽  
Ho Kyung Jung ◽  
Jae Hyung Ko ◽  
Mi Ok Sim ◽  
...  

2014 ◽  
Vol 29 (6) ◽  
pp. 125-132 ◽  
Author(s):  
Yeo-Hwan Yoon ◽  
Sung-Bae Kim ◽  
Ok-Hwa Kang ◽  
Su-Hyun Mun ◽  
Yun-Soo Seo ◽  
...  

KSBB Journal ◽  
2015 ◽  
Vol 30 (6) ◽  
pp. 326-331 ◽  
Author(s):  
Min-Ji Kim ◽  
Nan-Young Bae ◽  
Koth-Bong-Woo-Ri Kim ◽  
Ji-Hye Park ◽  
Sun-Hee Park ◽  
...  

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