scholarly journals Efficiency of Corticision in Accelerating Leveling and Alignment of Crowded Lower Anterior Teeth in Young Adult Patients: A Randomised Controlled Clinical Trial

2020 ◽  
Author(s):  
Mohamad Radwan Sirri ◽  
Ahmad S Burhan ◽  
Mohammad Y Hajeer ◽  
Fehmieh R Nawaya ◽  
Abdulaziz Abdulhadi
Keyword(s):  
Clinical Trial ◽  
Treatment Time ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Periodontal Tissues ◽  
Anterior Teeth ◽  
Attached Gingiva ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled ◽  
Leveling And Alignment

Introduction: The evaluation of flapless corticision in conjunction with the conventional treatment in the non-extraction decrowding of lower anterior teeth has not been performed yet in any randomised clinical trial, particularly in terms of treatment time and periodontal indices. Aim: The aim of the study was to compare the duration of leveling and alignment of mild and moderate crowding cases in the lower dental arch between the corticision-assisted fixed orthodontic treatment and the traditional method; and to compare the periodontal indexes between the two groups. Materials and Methods: A parallel-group Randomised Controlled Clinical Trial (RCT) was conducted on 60 patients (mean age 2 1.40±1.63 years). Patients were randomly assigned to either the corticision group or the control group (30 each). Immediately after fixed appliance bonding, three radiographic-guided incisions were performed on the labial surfaces of the alveolar bone between lower anterior teeth by reinforced scalpels and mallets in order to accelerate alignment for patients in the corticision group. Patients in the control group were treated with conventional orthodontics. The outcome measures were the overall time needed for leveling and alignment, periodontal parameters such as Plaque Index (PI), Probing Depth (PD), Gingival Index (GI), and the width of the attached gingiva. Results: The overall treatment time was significantly shorter in the corticision group than the control group. The average leveling and alignment period for the corticision group was 116.46±15.97 days, while it was 159.69±13.76 days in the control group. Comparing the groups, a significant reduction of about 27% was found in the leveling and alignment duration of the corticision group. There were no significant differences in the periodontal parameters (PI, PD, GI, the width of attached gingiva) at the end of leveling and alignment phase in both the groups. Conclusion: Corticision seems to be an effective method to accelerate leveling and alignment in cases of mild and moderate crowding. It did not cause negative effect on the periodontal tissues.

scholarly journals The control of pain due to dentin hypersensitivity in individuals with molar–incisor hypomineralisation: a protocol for a randomised controlled clinical trial

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e044653
Author(s):  
Ana Paula Taboada Sobral ◽  
Elaine Marcilio Santos ◽  
Ana Cecilia Aranha ◽  
Paulo Vinícius Soares ◽  
Caroline Moraes Moriyama ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Tooth Enamel ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Dentin Hypersensitivity ◽  
Molar Incisor Hypomineralisation ◽  
Randomised Controlled Clinical Trial ◽  
Sensitive Teeth ◽  
Randomised Controlled ◽  
Incisor Hypomineralisation

IntroductionDentin hypersensitivity (DH) is defined as high sensitivity of the vital dentin when exposed to thermal, chemical or tactile stimuli. Two mechanisms are required for the occurrence of DH: (1) the dentin must be exposed and (2) the dentinal tubules must be open and connected to the pulp. Molar–incisor hypomineralisation (MIH) is a qualitative abnormality of a genetic origin that affects tooth enamel and, in most cases, is accompanied by DH. The control of tooth sensitivity is fundamental to the successful treatment of MIH. The aim of the proposed randomised, controlled, clinical trial is to evaluate the effectiveness of different protocols for the control of DH in patients with teeth affected by MIH.Methods and analysisOne hundred and forty patients who meet the inclusion criteria will be allocated to four groups. Group 1 will be the control group (placebo). In Group 2, sensitive teeth will be sealed with PermaSeal (Ultradent). In Group 3, sensitive teeth will receive low-level laser (LLL, AsGaAl) at a wavelength of 780 nm (Laser XT Therapy, DMC, São Carlos, Brazil). In Group 4, sensitive teeth will be treated with both LLL and PermaSeal (Ultradent). DH will be evaluated 15 min after the application of the treatments and the patients will be reevaluated 1 week, 1 month, 3 months and 6 months after the treatments. The primary outcome of this study is change in pain/sensitivity, when evaluated through a Visual Analogue Scale, to determine the effectiveness of the proposed treatments, as well as differences among the evaluation times for each proposed treatment.Ethics and disseminationThis protocol has been ethically approved by the local medical ethical committee (protocol number: 4.020.261). Results will be submitted to international peer-reviewed journals and presented at international conferences.Trial registration numberNCT04407702.

scholarly journals Repetitive transcranial magnetic stimulation (rTMS) in autism spectrum disorder: protocol for a multicentre randomised controlled clinical trial

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e046830
Author(s):  
Peter G Enticott ◽  
Karen Barlow ◽  
Adam J Guastella ◽  
Melissa K Licari ◽  
Nigel C Rogasch ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Autism Spectrum Disorder ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Controlled Clinical Trial ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled

IntroductionThere are no well-established biomedical treatments for the core symptoms of autism spectrum disorder (ASD). A small number of studies suggest that repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, may improve clinical and cognitive outcomes in ASD. We describe here the protocol for a funded multicentre randomised controlled clinical trial to investigate whether a course of rTMS to the right temporoparietal junction (rTPJ), which has demonstrated abnormal brain activation in ASD, can improve social communication in adolescents and young adults with ASD.Methods and analysisThis study will evaluate the safety and efficacy of a 4-week course of intermittent theta burst stimulation (iTBS, a variant of rTMS) in ASD. Participants meeting criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ASD (n=150, aged 14–40 years) will receive 20 sessions of either active iTBS (600 pulses) or sham iTBS (in which a sham coil mimics the sensation of iTBS, but no active stimulation is delivered) to the rTPJ. Participants will undergo a range of clinical, cognitive, epi/genetic, and neurophysiological assessments before and at multiple time points up to 6 months after iTBS. Safety will be assessed via a structured questionnaire and adverse event reporting. The study will be conducted from November 2020 to October 2024.Ethics and disseminationThe study was approved by the Human Research Ethics Committee of Monash Health (Melbourne, Australia) under Australia’s National Mutual Acceptance scheme. The trial will be conducted according to Good Clinical Practice, and findings will be written up for scholarly publication.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12620000890932).

Moxibustion applied at home for non-vertex presentation: a multicentre randomised controlled clinical trial

2012 ◽  
Vol 4 ◽  
pp. 47
Author(s):  
Vas Jorge ◽  
Aranda-Regules José Manuel ◽  
Modesto Manuela ◽  
Barón Mercedes ◽  
Benítez-Parejo Nicolás ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Randomised Controlled Clinical Trial ◽  
Vertex Presentation ◽  
Randomised Controlled ◽  
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