scholarly journals Anticancer Efficacy of Thevetia peruviana (Pers.) K. Schum. Extracts on Triple Negative Human Breast Cancer Cell Line

2020 ◽  
pp. 64-69
Author(s):  
S. Rajhans ◽  
K. Bhadresha ◽  
D. K. Yadav ◽  
R. M. Rawal ◽  
H. A. Pandya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Triple Negative ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast

In this 21st century cancer has become the second big reason for death next to heart attack in both developed and the developing countries.  Worldwide, there are almost 2.1 million newly diagnosed breast cancer cases in 2018, accounting for 1 in 4 cancer cases among women. Triple Negative Human Breast Cancer is one of the types of human breast cancer. The plant extracts of Thevetia peruviana (Pers.) K. Schum. has been used against the Triple Negative Human Breast Cancer cell line MDA-MB-231 for the current experiment All the 5 parts (leaf, stem, flower, fruit and seed) had been selected for the experiment and the extracts of the various parts were made in hydro-alcoholic solvent i.e. methanol: Water.

scholarly journals Raloxifene Inhibits Estrogen-induced Up-regulation of Telomerase Activity in a Human Breast Cancer Cell Line

2003 ◽  
Vol 278 (44) ◽  
pp. 43363-43372 ◽  
Author(s):  
Jun Kawagoe ◽  
Masahide Ohmichi ◽  
Toshifumi Takahashi ◽  
Chika Ohshima ◽  
Seiji Mabuchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Telomerase Activity ◽  
Human Breast Cancer Cell ◽  
Human Breast

Human breast cancer cell inhibitory constituents from Tetradium ruticarpum

2021 ◽  
Vol 66 (1) ◽  
pp. 65-71
Author(s):  
Hung Nguyen Phi ◽  
Toan Tran Quoc ◽  
Tuan Nguyen Anh ◽  
Vy Trinh Ngoc Thao ◽  
Yen Ngo Thi Ngoc ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Mcf 7

Three alkaloids (named rutaecarpine (1), evodiamine (2), schinifoline (3) and one phenylpropanoid, integrifoliodiol (4)) have been isolated from the EtOAc extract of the fruits of Tetradium ruticarpum (A. Juss.) T. G. Hartley collected in Lang Son province. Their structures have been identified by using 1D and 2D NMR spectroscopies. All four compounds were tested for their cytotoxicity against the human breast cancer cell line (MCF-7) and tamoxifen-resistant breast cancer cell line (MCF\TAMR). The results showed that rutaecarpine (1) inhibited the growth of MCF7 and MCF\TAMR with its IC50 values of 41.2 and 64.6 µM, respectively. In addition, compounds 1, 2, and 4 showed moderate activity toward MCF-7 cell line.

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