Kinetics and Mechanism of Oxidation of Gabapentin by N-bromosuccinimide in Aqueous Alkaline Medium. Comparing to the Kinetics of Oxidation by N-bromosuccinimide in Aqueous Acid Medium

2014 ◽  
Vol 4 (1) ◽  
pp. 76-87 ◽  
Author(s):  
Alaa Abdel-Hady
Keyword(s):  
Acid Medium ◽  
Alkaline Medium ◽  
Kinetics And Mechanism ◽  
Aqueous Alkaline Medium ◽  
Kinetics Of Oxidation ◽  
Aqueous Acid ◽  
Mechanism Of Oxidation ◽  
Kinetics Of

Kinetics and Mechanism of Oxidation of Aliphatic Primary Alcohols with 1-Chlorobenzimidazole in Aqueous Acetic Acid Medium

2016 ◽  
Vol 230 (8) ◽  
Author(s):  
Muthusamy Rukmangathan ◽  
Vetrivel Santhoshkumar ◽  
Balasubramanian Ramkumar
Keyword(s):  
Acetic Acid ◽  
Acid Medium ◽  
Kinetics And Mechanism ◽  
Aqueous Acetic Acid ◽  
Primary Alcohols ◽  
Acetic Acid Medium ◽  
Kinetics Of Oxidation ◽  
First Order ◽  
Mechanism Of Oxidation ◽  
Kinetics Of

AbstractThe kinetics of oxidation of a few aliphatic primary alcohols with 1-chlorobenzimidazole (CBI) was studied in aqueous acetic acid medium. The reactions were found to be first order each with respect to the concentrations of CBI and alcohol. The added HClO

A Study of Substituent Effect on the Oxidative Strengths of N-Chloroarenesulphonamides: Kinetics of Oxidation of Leucine and Isoleucine in Aqueous Acid Medium

2004 ◽  
Vol 59 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Mahesha Shetty ◽  
B. Thimme Gowda
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Ionic Strength ◽  
Acid Medium ◽  
Benzene Ring ◽  
Thermodynamic Data ◽  
Substituent Effect ◽  
Kinetics Of Oxidation ◽  
Aqueous Acid ◽  
Kinetics Of

Abstract To study the variation of oxidative strengths of N-chloro-arenesulphonamides with substitution in the benzene ring, six mono- and five di-substituted N-chloro-arenesulphonamides are employed as oxidants for studying the kinetics of oxidation of two neutral amino acids, L-leucine and Lisoleucine in aqueous acid medium. The N-chloro-arenesulphonamides studied are of the constitution: ArSO2NaNCl·H2O (where Ar = C6H5, 4-CH3C6H4, 4-C2H5C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 2,3-(CH3)2C6H3, 2,4-(CH3)2C6H3, 2-CH3-4-ClC6H3, 2,4-Cl2C6H3, and 3,4-Cl2C6H3). The reactions show second order kinetics in [oxidant], fractional order in [amino acid] and inverse dependence on [H+]. Addition of the reduced product of the oxidants or variation in ionic strength of the medium has no significant effect on the rates of oxidations. A two-pathway mechanism is considered to explain the experimental results. Effective oxidizing species of the oxidants is Cl+ in different forms. Therefore the oxidising strengths of N-chloro-arenesulphonamides depend on the ease with which Cl+ is released from them. The study reveals that the introduction of substituent in the benzene ring of the oxidant affects both the kinetic and thermodynamic data for the oxidations The electron releasing groups such as CH3 generally inhibit the rates, while electron-withdrawing groups such as Cl enhance this ability, as the electron withdrawing groups ease the release of Cl+ from the reagents and hence increase the oxidising strengths. The on Ea and logA and validity of the Hammett and isokinetic relationships for the oxidations are also analysed.

scholarly journals Kinetics and Mechanism of Oxidation ofL-Cystine by Hexacyanoferrate(III) in Alkaline Medium

2009 ◽  
Vol 6 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Annapurna Nowduri ◽  
Kalyan Kumar Adari ◽  
Nageswara Rao Gollapalli ◽  
Vani Parvataneni
Keyword(s):  
Alkaline Medium ◽  
Oxidation Product ◽  
Experimental Results ◽  
Cysteic Acid ◽  
Kinetics Of Oxidation ◽  
First Order ◽  
Order Dependence ◽  
Plausible Mechanism ◽  
Mechanism Of Oxidation ◽  
Kinetics Of

Kinetics of oxidation ofL-cystine by hexacyanoferrate(III) was studied in alkaline medium at 30 °C. The reaction was followed spectrophotometrically at λmax = 420 nm. The reaction was found to be first order dependence each on [HCF(III)] and [cystine]. It was found that the rate of the reaction increases with increase in [OH-]. The oxidation product of the reaction was found to be cysteic acid. A plausible mechanism has been proposed to account for the experimental results.

Oxidation of (+)-(R)-Pantothenic Acid by Aqueous Alkaline Potassium Permanganate: A Kinetic and Mechanistic Approach

2002 ◽  
Vol 216 (6) ◽  
Author(s):  
S.M. Desai ◽  
N.N. Halligudi ◽  
S.K. Mavalangi ◽  
S.T. Nandibewoor
Keyword(s):  
Ionic Strength ◽  
Potassium Permanganate ◽  
Alkaline Medium ◽  
Pantothenic Acid ◽  
Constant Ionic Strength ◽  
Aqueous Alkaline Medium ◽  
Kinetics Of Oxidation ◽  
Mechanistic Approach ◽  
Kinetics Of

The kinetics of oxidation of (+)-(R)-pantothenic acid (PA) by permanganate in aqueous alkaline medium at constant ionic strength 0.20 mol dm

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