scholarly journals Long COVID Syndrome Presenting as Hyperferritenemia Associated Toxic Encephalopathy in a Deferoxamine Compliant Patient of Beta Thalassemia

2021 ◽  
pp. 241-246
Author(s):  
Sujal Patel ◽  
Dhruv Talwar ◽  
Sunil Kumar ◽  
Sourya Acharya ◽  
Mansi Patel
Keyword(s):  
Index Case ◽  
Thalassemia Major ◽  
Toxic Encephalopathy ◽  
Beta Thalassemia ◽  
Mortality And Morbidity ◽  
Important Complication ◽  
Compliant Patient ◽  
Thalassemia Major Patient ◽  
Frequent Problem ◽  
Important Marker

Ferritin overload is a frequent problem encountered in patients with beta thalassemia amounting to various complications. One of rare but important complication of ferritin overload is ferritin overload induced toxic encephalopathy. Serum ferritin has been recognised as a important marker of inflammation and cytokine storm in COVID19.We present a case of Long COVID syndrome presenting as toxic encephalopathy in a case of beta thalassemia in spite of the patient being compliant to desferroxamine therapy.This report highlights the synergistic effect of Severe Acute Respiratory Syndrome Coronavirus. 2(SARS CoV 2) mediated neuroinflammation through direct viral invasion and the release of inflammatory cytokines including ferritin  resulting in toxic encephalopathy in a beta thalassemia major patient who was already prone to develop hyperferritenemia.Ferritin functions as a pro-inflammatory cytokine and it’s level increases in both thalassemia and COVID-19 and the index case presented here had both the conditions predisoposing him to develop toxic encephalopathy even after being compliant to deferoxamine therapy. It is important to recognise and treat this condition in order to prevent mortality and morbidity in patients of beta thalassemia who contract COVID19.

Beta Thalassemia Major with Diabetes Mellitus: A Case Report

2021 ◽  
Vol 8 (2) ◽  
pp. 85-88
Author(s):  
Dr. Sneha Mhaske ◽  
Dr. Abhijit Shinde ◽  
Dr. Sonal Shinde ◽  
Dr. Ramesh Kothari ◽  
Dr. Ganesh Misal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar Level ◽  
Chelating Agent ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Laboratory Examination ◽  
Beta Thalassemia Major ◽  
Thalassemia Major Patient ◽  
Urine Sugar ◽  
Hemoglobin Production

Thalassemia results from defects in normal hemoglobin production, and represents the most common inherited anemia worldwide. Diabetes is a complication of b-thalassemia major. We report a case of Diabetes mellitus in a known case of beta thalassemia major. Patient had undergone Splenectomy 1 year back. Patient is taking chelating agent Defasirox 1000mg orally once a day in the morning. Family history reveals, born through third degree consanguineous marri age. The patient was then subjected for laboratory examination reveals BSL was high, urine ketone 2+,urine sugar 3+, ABG was normal, HbA1c was 13 & 3 month old report of  serum ferritin 1200 ng/dl. Multidisciplinary management was instituted. Blood sugar level got controlled over subcutaneous insulin. Patient may have landed in Diabetic ketoacidosis but was promptly diagnosed & treated. This case is presented for its rarity. As the life expectancy of patients with thalassaemia increases, this will also expose our patients potentially to many more years of hyperglycaemia and diabetes. Sustaining metabolic control and controlling cardiovascular risk factors will be critical in the future for preventing complications due to diabetes.

scholarly journals Watershed Infarct in Beta-Thalassemia Major Patient

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Behnaz Ansari ◽  
Mohammad Saadatnia ◽  
Ali Asghar Okhovat
Keyword(s):  
High Risk ◽  
Internal Carotid ◽  
Thalassemia Major ◽  
Carotid Occlusion ◽  
Beta Thalassemia ◽  
Severe Anemia ◽  
Thalassemia Major Patient ◽  
Risk Patients ◽  
Internal Carotid Occlusion ◽  
Acute Brain Ischemia

Background. The mechanism of stroke in beta-thalassemia was reported previously as cardioembolic and hypercoagulable state. However, there is no report of watershed infarct in beta-thalassemia anemia.Method. We present an adultβ-thalassemia major patient with manifest asymptomatic chronic left carotid occlusion who suffered watershed infarct.Result. In the presence of asymptomatic chronic left internal carotid occlusion, we assumed that severe anemia (hemoglobin = 3) at admission leads to watershed infarct.Conclusion. Watershed infarct seems to be the cause of stroke in cases ofβ-thalassemia major with severe anemia. Blood transfusion can be applied in the setting of acute brain ischemia in such high risk patients.

scholarly journals Serum ferritin levels and it’s correlation with cardiac iron overload with the help of cardiac T2* magnetic resonance imaging

2021 ◽  
Vol 8 (8) ◽  
pp. 1374
Author(s):  
Shailaja V. Mane ◽  
Sharad Agarkhedkar ◽  
Dyaneshwar Upase ◽  
Tushar Kalekar ◽  
P. Sindhura
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Resonance Imaging ◽  
Mortality And Morbidity ◽  
T2 Mri

Background: Frequent blood transfusions in thalassemia major is associated with iron overload in these patients. To reduce the mortality and morbidity, proper usage of iron chelators is necessary to treat iron overload. Cardiac magnetic resonance imaging (MRI) guides in quantification of iron overload in heart. The purpose of this study is to see the correlation between serum ferritin level and T2* MRI in patients with beta thalassemia major.Methods: Period of the study is September 2018 to September 2020. Total 25 patients diagnosed with β-thalassemia major above 5 years of age were enrolled in the study. They were on regular transfusions. Cardiac T2* MRI was done in these patients and correlated with serum ferritin levels.Results: There was no significant correlation observed between cardiac T2* MRI and serum ferritin values (p=0.66, r=-0.094).Conclusions: Our results showed no significant correlation between serum ferritin and cardiac T2* MRI values. Ferritin alone cannot be used as index of myocardial iron overload in thalassemia major.

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