New Levenshtein-Marker Code for DNA-based Data Storage Capable of Correcting Multiple Edit Errors

With the development of DNA synthesis and sequencing technologies, DNA becomes a promising medium forlong-term data storage. Three types of errors may occur in the DNA strand, insertions, deletions and substitutions,which we collectively call edit errors. It is still challenging to design a code that can correct multiple edit errors onnon-binary alphabets. In this paper, we propose a new coding schema for correcting multiple edit errors on DNAstrands by splitting the whole strand into consecutive blocks with appropriate length and correcting a single editerror in each block. Our method, called theDNA-LMcode, could be considered a generalization of the Levenshteincode combined with the marker code. We provide a linear encoding and decoding algorithm for ourDNA-LMcode.Compared to other encoding methods for DNA strands of several hundred base-pairs, ourDNA-LMcode achievedsimilar code rates and a much lower average nucleotide error rate in decoding.

New Levenshtein-Marker Code for DNA-based Data Storage Capable of Correcting Multiple Edit Errors

With the development of DNA synthesis and sequencing technologies, DNA becomes a promising medium forlong-term data storage. Three types of errors may occur in the DNA strand, insertions, deletions and substitutions,which we collectively call edit errors. It is still challenging to design a code that can correct multiple edit errors onnon-binary alphabets. In this paper, we propose a new coding schema for correcting multiple edit errors on DNAstrands by splitting the whole strand into consecutive blocks with appropriate length and correcting a single editerror in each block. Our method, called theDNA-LMcode, could be considered a generalization of the Levenshteincode combined with the marker code. We provide a linear encoding and decoding algorithm for ourDNA-LMcode.Compared to other encoding methods for DNA strands of several hundred base-pairs, ourDNA-LMcode achievedsimilar code rates and a much lower average nucleotide error rate in decoding.

FEATURES OF THE FIGURATIVE LANGUAGE OF ESSAYIST Y. KOSACH

The article investigates rhetorical figures and specific authorial constructions, which are interconnected through a complex sequence of semantic connections, forming the essay. On the example of the essay by Y. Kosach “On the Meeting of the 17th Anniversary of November”, the role of figurative language in the study of cultural meanings is researched. For this purpose, Visnik text constructions with a powerful sense-forming potential are considered, which are not only examples of expanded essayistic imagery, but also a kind of cultural marker, code, according to R. Bart, on which Yu.Kosach always focuses on his essays. Particular attention is paid to “ thoughtful image” texts by D. Dontsov, Y. Lipi, E. Malanyuk, as well as interpretations by these authors of the most important problems of the Ukrainian national character, from which Y. Kosach rests in his reflections. Kosach`s essay is completely transposed with symbolic-figurative signs (codes), whose meaning can be understood, not only knowing in detail the national history and heroes, the history of literature, ethnography and ethnopsychology, philosophy and mythology, but also the political, ideological, cultural-historical context . In the essay actively present the basic ideas and works of D. Dontsov, Y. Lypa, E. Malanyuk, and others. In order to study the interdependence of thought and image in essayist Y. Kosach, the “mysterious” nature of historical events, national heroes, state symbols, geographical names and names of settlements is analyzed in detail. The problem of essayist’s elaboration of individual words, statements and plain citations is considered, attention is focused on multilevel semantic complexes-figures. The Kosach style is characterized by spontaneity, fragmentation, emotionality, openness, associativity of the thinking process. The essay combines different discourses, demonstrating the free movement of thought, not limited by the rigid frame of the canon. For Kosach, the most important thing was to isolate, reinforce, and to emphasize the strong peculiarities of the national psyche; to follow the kinship not only of the bloody but also of the spirit-knight and to draw a continuous line of continuity.

Markers of assimilation of problematic experiences in dementia within the LivDem project

This study aimed to determine whether the Markers of Assimilation of Problematic Experiences in Dementia scale (MAPED) can be used to identify whether the way in which participants talk about dementia changed during the group. All eight sessions of a LivDem group, which were attended by participants were recorded and transcribed. An initial analysis identified 160 extracts, which were then rated using the MAPED system. Inter-rater reliability was 61% and following a resolution meeting, 35 extracts were discarded, leaving 125 extracts with an agreed marker code. All of the participants were identified as producing a speech marker relating to dementia, and these varied between 0 (warding off) to 6 (problem solution). Examples of these markers are provided. The proportion of emergence markers (indicating the initial stages of assimilation) compared to later markers changed significantly between the first four sessions and the final sessions. This difference was still significant even when the markers produced by the most verbal participant, Graham, were excluded. The use of process measures within psychotherapy complements more conventional outcome measures and has both theoretical and clinical implications.