Zhongwei station of West to east natural gas pipeline is connected to the north of Zhonggui line, and Guiyang station of China-Myanmar natural gas pipeline is connected to the south, which has important strategic significance in Southwest China. At present, the tie line mainly carries out gas transmission from Zhongwei to Guiyang. Only some pipeline sections and offload stations have reverse transmission function, while all compressor stations have no reverse transmission and pressurization function. In order to evaluate the flexibility of the operation of the Zhonggui line and give some suggestions for the preliminary reconstruction, this paper uses the SPS software to establish the pipeline model and simulate the specific working conditions, focusing on the two working conditions of the intermediate station injection forward transmission and the whole line reverse transmission. Through the simulation, we can get the following conclusions: 1. When the intermediate station injects forward gas transmission, which compressor station, gas transmission range and joint operation condition with China-Myanmar line need to be started for Zhonggui line; 2. When the whole tie line is reversed, it is necessary to change the location of the compressor station with the function of reverse transmission and pressurization. Through this study, we can give some reference and evaluation opinions on the lack of flexibility of the current tie line, and also give some reference opinions on the specific implementation of the improvement of the tie line operation flexibility in the future.