Recent advances in the synthesis of α-amino ketones

This review on α-amino ketone synthesis collates and evaluates developments made in this area over the past decade, with an extended discussion on functional group compatibility, resultant product substitution patterns, and medicinal applications.

Preparation and facile addition reactions of iminium salts derived from amino ketene silyl acetal and amino silyl enol ether

While iminium salts generated from amino ketene silyl acetals react with silyl enol ethers, those from amino silyl enol ethers also undergo facile addition reactions to give alpha-amino ketone derivatives in good yields.

Mechanistic investigation-inspired activation mode of DBU and the function of the α-diazo group in the reaction of the α-amino ketone compound and EDA: [DBU-H]+-DMF-H2O and α-diazo as strong N-terminal nucleophiles

DFT calculations disclosed a dramatic electronic turnover of the α-diazo group based on an unexpected DBU activation mode.