This book explores the notion of causal constraint in science. It examines a family of general constraints encountered in fundamental science, along with the conceptual relations between them: determinism, locality, stability, symmetries, conservation laws, and variation principles. The book shifts the focus away from causal relations between individual events (or properties of events) to the more general causal constraints found in science. This chapter discusses the main contending philosophical accounts of causation and the key issues they raise, including regularity theories (also known as Humean theories), the counterfactual account advanced by David Lewis, process accounts, probabilistic accounts, and interventionist or manipulation accounts. It also provides an overview of determinism, locality, stability, symmetries, conservation laws, and variation principles, along with causal asymmetry and the mutuality of causal relations.