Energy from the Sun brings as Solar energy which is abundantly available and utilized for various applications. Owing to the increase in energy demand, having a limit of non-renewable energy sources, more interest is given to Solar energy. One of the most fundamental applications of using Solar energy is a Solar collector. The efficiency of the Solar collector depends upon the fluids used in the Solar collector and thermal performance also can be enhanced by using heat pipes in the Solar collector. Compared to flat plate solar collectors, the major disadvantage of heat loss can be rectified in heat pipe solar collectors. Still, to improve the performance of heat pipe solar collectors, nanofluids can be used instead of base fluids to improve thermal performance. In this review paper, the application of nanofluid in Solar collectors results in the percentage of improvement in heat transfer by nanofluid at optimum condition is discussed. This paper reviewed widely the recent development and upcoming research that can be done to enhance the working of heat pipe Solar collectors using nanofluids.