cationic surfactants
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2022 ◽  
Yihan Liu ◽  
Yanan Han ◽  
Zhaohui Huang ◽  
Ping Qi ◽  
Aixin Song ◽  

A nonionic poly(oxyethylene) monoalkyl ether (C12(EO)6) and a cationic hexadecylpyridinium bromide (HPB) were used in featuring warm/cool transparency transition switchability, depending on the decrease in the hydration of the EO-headgroup...

2021 ◽  
Alla B Mirgorodskaya ◽  
Marina Koroleva ◽  
Rushana A Kushnazarova ◽  
Ekaterina V Mishchenko ◽  
Konstantin A. Petrov ◽  

Abstract In this work, a noncovalent strategy was successfully used to modify colloidal stability and in vitro and in vivo efficacy of two amphiphilic formulations of the anti-inflammatory drug indomethacin. Namely, nanoemulsions and microemulsions based on oleic acid and nonionic surfactants have been produced and compared. The influence of cationic surfactants cetyltrimethylammonium bromide and its carbamate bearing analogue on the size characteristics, stability and ability to provide prolonged action of loaded drug indomethacin has been evaluated. Adding the positively charged molecules in the surface layer of nanoemulsions and microemulsions has shown the stability increase along with maintaining the size characteristics and homogeneity in time. Moreover, the carbamate modified analogue demonstrated beneficial behavior. Indomethacin loaded in microemulsions and nanoemulsions showed prolonged-release (10 to 15% release for 5 h) compared to a free drug (complete release for 5 h). The rate of release of indomethacin from nanoemulsions was slightly higher than from microemulsions and insignificantly decreased with an increase in the concentration of the cationic surfactant. For carbamate surfactant nanocarrier loaded with fluorescence probe Nile red, the ability to penetrate into the cell was supported by flow cytometry study and visualized by fluorescence microscopy. In vitro tests on anti-inflammatory activity of the systems demonstrated that the blood cell membrane stabilization increased in the case of modified microemulsion. The anti-inflammatory activity of the encapsulated drug was tested in rats using a carrageenan-induced edema model. Nanoemulsions without cationic surfactants appeared more efficient compared to microemulsions. Indomethacin emulsion formulations with carbamate surfactant added showed slower carrageenan-induced edema progression compared to unmodified compositions. Meanwhile, the edema completely disappeared upon treatment with emulsion loaded indomethacin after 4 h in the case of microemulsions versus 5 h in the case of nanoemulsions.

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
farid El-Dossoki ◽  
Samir abedelhady ◽  
Mona Abedalhmeed ◽  
Manar Abdel-Raouf ◽  
Ahmed Ali

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