Non-functional neuroendocrine tumor with multisystemic metastasis in a cat

An eight-year-old castrated female feline was referred for necropsy with a history of apathy, inappetence, abdominal distension, hypersensitivity to abdominal palpation, and evidence of abdominal neoplasms on ultrasound. Macroscopically, multifocal to coalescent, yellowish-white, firm and infiltrative nodules were observed on the surface of the parietal peritonium and in abdominal and thoracic organs. Microscopic characteristics of the neoplasm suggested a neuroendocrine origin, but did not allow a definitive diagnosis and determination of the origin. Immunohistochemistry revealed that neoplastic cells expressed vimentin, CD56, neuron specific enolase, and PGP 9.5 and were negative for biogenic amines and hormonal peptides. Based on anatomopathological and immunohistochemical findings, diagnosis of metastatic non-functional neuroendocrine tumor was confirmed.

Diagnosis of cognitive function changes in patients with abdominal neoplasms occurring in the early postsurgery period and management of those with neuroprotective drug

Background. The issue of analysis of diagnostic criteria and adequate neuroprotective management of postsurgery cognitive dysfunction in abdominal oncosurgery, depending on the degree and structure of disorders, remains unresolved, determining its relevance. Purpose – assessing the postsurgery cognitive dysfunction in patients with neoplasms of the abdominal cavity and management of possible disorders with citicoline depending on the level of general cognitive deficit. Materials and methods. TThe study was conducted at the premises of departments for patients of surgical profile of Municipal Institution “Kharkov City Clinical Hospital of Ambulance and Emergency Care named after Professor O.I. Meshchaninov”. To achieve the aim of the study, 80 patients with abdominal neoplasms who underwent surgery under general anesthesia using propofol and fentanyl were examined. Results and discussion. Based on the comprehensive clinical study and anal- ysis of the mechanisms of formation of postsurgery cognitive dysfunction in patients of oncosurgical profile after surgery under general anesthesia, we suggested directions and schemes for managing postsurgery cognitive dysfunction by means of the developed clinical diagnostic criterion, which is essential in forming individual scheme of treating patients in postsurgery period. Conclusions. Based on the analysis of data on the state of cognitive function changes, comparing the postsurgery period with the preoperative state, a differentiated approach to intensive neuroprotective therapy of postoperative cognitive dysfunction was developed. The technique of intensive neuroprotective therapy of postsurgery cognitive dysfunction in patients with abdominal neoplasms, undergoing surgery under general anesthesia, was suggested.