Tolerance of Rilmenidine and its combination with amlodipine in hypertensive patients (according to ALTAIR study)

The aim of the study was lo evaluate tolerance of rilmenidine and its combination with amlodipine in ALTAIR study population. The study included 677 patients. 610 (90.4 %) completes it successfully. 126 adverse events have been observed, but only in 4.4 % cases it lead to therapy discontinuation. Adverse events were most frequent on i week visit, later due to excluding of some patients and disappearance of several adverse events its rate. The most frequent adverse effect was dry mouth which was registered in 64 (9.5 %) patients. In conclusion, analysis of ALTAIR data indicates that rilmenidine is well tolerated taking alone оr in combination with amlodipine in patients with mold-to-moderate hypertension. Moreover, rilmenidine therapy is accompanied by improvement of quality of life.