Tolerance of Rilmenidine and its combination with amlodipine in hypertensive patients (according to ALTAIR study)

The aim of the study was lo evaluate tolerance of rilmenidine and its combination with amlodipine in ALTAIR study population. The study included 677 patients. 610 (90.4 %) completes it successfully. 126 adverse events have been observed, but only in 4.4 % cases it lead to therapy discontinuation. Adverse events were most frequent on i week visit, later due to excluding of some patients and disappearance of several adverse events its rate. The most frequent adverse effect was dry mouth which was registered in 64 (9.5 %) patients. In conclusion, analysis of ALTAIR data indicates that rilmenidine is well tolerated taking alone оr in combination with amlodipine in patients with mold-to-moderate hypertension. Moreover, rilmenidine therapy is accompanied by improvement of quality of life.

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Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life

Supportive Care in Cancer ◽

10.1007/s00520-021-06066-3 ◽

2021 ◽

Author(s):

Mikiko Kaizu ◽

Hiroko Komatsu ◽

Hideko Yamauchi ◽

Teruo Yamauchi ◽

Masahiko Sumitani ◽

...

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Peripheral Neuropathy ◽

Adverse Events ◽

Cross Sectional Study ◽

Dry Mouth ◽

Cross Sectional ◽

Independent Risk Factors ◽

Taste Alteration

Abstract Purpose There is limited evidence on the effect of chemotherapy-associated taste alteration. This study aimed to evaluate taste alteration characteristics in patients receiving taxane-based chemotherapy and investigate the association of taste alterations with appetite, weight, quality of life (QOL), and adverse events. Methods This cross-sectional study evaluated 100 patients receiving paclitaxel, docetaxel, or nab-paclitaxel as monotherapy or combination therapy. Taste alterations were evaluated using taste recognition thresholds and severity and symptom scales. Taste recognition thresholds, symptoms, appetite, weight, and adverse events were compared between patients with and without taste alterations, and logistic regression analysis was performed to identify risk factors. Results Of the 100 patients, 59% reported taste alterations. We found significantly elevated taste recognition thresholds (hypogeusia) for sweet, sour, and bitter tastes in the taste alteration group receiving nab-paclitaxel (p = 0.022, 0.020, and 0.039, respectively). The taste alteration group reported general taste alterations, decline in basic taste, and decreased appetite. Neither weight nor QOL was associated with taste alterations. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were significantly associated with taste alterations. Conclusions Almost 60% of patients receiving taxane-based regimens, especially docetaxel, reported taste alterations. Taste alteration affected the patient’s appetite but did not affect the weight or QOL. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were independent risk factors for taste alterations.

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▾ Celiprolol – a better beta blocker?

Drug and Therapeutics Bulletin ◽

10.1136/dtb.30.9.35 ◽

1992 ◽

Vol 30 (9) ◽

pp. 35-36

Keyword(s):

Quality Of Life ◽

Cardiovascular Risk ◽

Beta Blocker ◽

Moderate Hypertension ◽

Risk Profile ◽

Cardiovascular Risk Profile ◽

Once Daily ◽

Hypertensive Patients ◽

Β Blocker

Celiprolol (Celectol – Rhoône Poulenc Rorer) is a new cardioselective β-blocker and vasodilator, intended for once daily treatment of mild to moderate hypertension. The manufacturer claims that “it improves the overall cardiovascular risk profile” and gives hypertensive patients “a better quality of life than can be expected from conventional β-blocker treatment”. We examine these claims.

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The Adverse Effects Reporting of Antibiotic Induced Diarrhea

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2020/v32i530433 ◽

2020 ◽

pp. 28-32

Author(s):

Nehad J. Ahmed

Keyword(s):

Quality Of Life ◽

Adverse Effect ◽

Saudi Arabia ◽

Retrospective Study ◽

Adverse Effects ◽

Adverse Events ◽

Drug Safety ◽

Gastrointestinal Adverse Effect ◽

Amoxicillin Clavulanate

Introduction: In Saudi Food and Drug Authority, there is a center called National Pharmacovigilance and Drug Safety Center responsible for adverse events reporting. This study aims to demonstrate the antibiotic induced diarrhea reporting by National Pharmacovigilance and Drug Safety Center in Saudi Arabia. Methodology: This is a retrospective study about the reporting of diarrhea adverse effects caused by antibiotics. The data were collected from the adverse effects reports that were submitted to Saudi Food and Drug Authority in 2017 and 2018. Results: Gastrointestinal adverse effects reports were mainly for penicillin antibiotics. The major gastrointestinal adverse effect of penicillin was diarrhea (100 reports out of 147 reports for penicillin include diarrhea). Most of the diarrhea reports were caused by Amoxicillin/Clavulanate followed by Amoxicillin. Conclusion: One of the major adverse effects for antibiotics is diarrhea that is mainly occurred by penicillin antibiotics. The majority of cases of antibiotics-associated diarrhea are not serious, but still affect the patients’ quality of life. Therefore, it is important to increase the awareness regarding medications adverse effects and their reporting.

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Improvements in multiple domains of quality of life with alemtuzumab as assessed by the functional assessment of multiple sclerosis questionnaire over 6 years regardless of presence of thyroid adverse events

10.26226/morressier.5b7578655aff7400151f35ff ◽

2018 ◽

Author(s):

Aaron Boster

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Adverse Events ◽

Functional Assessment ◽

Multiple Domains

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Proton Pump Inhibitors in 2021: Pros, Cons, and Everything in Between

Foregut: The Journal of the American Foregut Society ◽

10.1177/26345161211021766 ◽

2021 ◽

pp. 263451612110217

Author(s):

Joshua A. Sloan ◽

Philip O. Katz

Keyword(s):

Quality Of Life ◽

Side Effects ◽

Adverse Events ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Drug Class ◽

Life Threatening

The medical and lay literature has exploded with reports of adverse events associated with proton pump inhibitors over the last 10 to 15 years. The dissemination of these reports to patients and clinicians have created substantial concerns regarding what has been an exceptionally valuable drug class, dramatically improving patient quality of life, and in many cases preventing life threatening side effects of other medication. Patients are more frequently seeking to avoid these medications, and practitioners are reducing or discontinuing them to the patient’s detriment due to a misunderstanding of the data. This review will discuss the data regarding the most commonly publicized adverse events and attempt to put them in perspective.

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Patient-reported quality-of-life outcomes in relation to provider-assessed adverse events during head and neck radiotherapy

Journal of Patient-Reported Outcomes ◽

10.1186/s41687-020-00227-4 ◽

2020 ◽

Vol 4 (1) ◽

Author(s):

Joshua R. Niska ◽

Cameron S. Thorpe ◽

Michele Y. Halyard ◽

Angelina D. Tan ◽

Pamela J. Atherton ◽

...

Keyword(s):

Quality Of Life ◽

Adverse Events ◽

Head And Neck ◽

Life Outcomes ◽

Quality Of Life Outcomes ◽

Patient Reported ◽

Head And Neck Radiotherapy

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The Relationship between Restless Legs Syndrome and Quality of Life in Patients with Myasthenia Gravis

European Neurology ◽

10.1159/000502002 ◽

2019 ◽

Vol 81 (3-4) ◽

pp. 205-208

Author(s):

Monica F. Ataide ◽

Carolina da Cunha-Correia ◽

Katia C.L. Petribú

Keyword(s):

Quality Of Life ◽

Myasthenia Gravis ◽

Restless Legs Syndrome ◽

Rating Scale ◽

Cross Sectional Study ◽

Cross Sectional ◽

Restless Legs ◽

Study Population ◽

Clinical Conditions

Background: Restless legs syndrome (RLS) is characterized for an uncomfortable sensation in legs and an irresistible desire to move them. This disorder has been more recently recognized in patients with myasthenia gravis (MG) and can interfere with the quality of life (QOL). Objectives: The aims of this study are to describe the prevalence of RLS and its severity and influence on the QOL in patients with MG. Method: This was a cross-sectional study conducted from May to June 2016 in Recife, Brazil. A sample of 42 patients was interviewed using a sociodemographic questionnaire, MG QOL questionnaire-15 and The RLS Rating Scale. Results: RLS was present in 47.6% of patients and of these 40.5% met moderate to severe RLS criteria. Patients were 45 years on average (SD ± 14.4) and women represented 57.1% of the study population. Among patients with RSL, the quality-of-life scores were worse (p = 0.010) on average. There was no association of RLS with the duration of MG, use of immunosuppressant or clinical conditions that could mimic the occurrence of RLS. Conclusion: RLS is a prevalent condition in patients with MG, and may be severe enough to negatively impact QOL.

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