hashimoto’s encephalopathy
Recently Published Documents


TOTAL DOCUMENTS

322
(FIVE YEARS 62)

H-INDEX

28
(FIVE YEARS 3)

Author(s):  
Yasser Aladdin ◽  
Bader Shirah

AbstractHashimoto's encephalopathy is a rare immune-mediated disorder characterized by subacute encephalopathy with elevated thyroid antibodies. Hashimoto's encephalopathy is also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis. We report a rare presentation of Hashimoto's encephalopathy presenting with acute neuropsychiatric disturbances, rapidly progressive dementia, seizures, and extrapyramidal failure. Neuroimaging revealed multifocal vasculitides of major cerebral vessels that support the autoimmune vasculitic theory as the underlying pathogenesis for Hashimoto's encephalopathy. Unfortunately, permanent irreversible cerebral damage has already ensued before her presentation to our center, which rendered steroid therapy ineffective. Serological testing for Hashimoto's thyroiditis must be in the investigation of all rapidly progressive dementias as early diagnosis and timely management of autoimmune thyroiditis may salvage sizable and eloquent cerebral tissues. The rarity of the condition should not preclude the investigation of Hashimoto's disease even in the presence of normal levels of thyroid hormones. Delayed diagnosis may result in irreversibly catastrophic encephalopathy in patients who once presented with potentially curable dementia.


2021 ◽  
Author(s):  
Maha Khalid ◽  
Mohamed Malik ◽  
Samantha Anandappa ◽  
Siva Sivappriyan ◽  
Jesse Kumar

2021 ◽  
pp. 102895
Author(s):  
Ching-Heng Tsai ◽  
Kuan-Tang Yu ◽  
Hung-Yu Chan ◽  
Chia-Hsiang Chan

2021 ◽  
Vol 429 ◽  
pp. 118788
Author(s):  
Davide Quartana ◽  
Federica Masuzzo ◽  
Diletta Mannina ◽  
Sabrina Gasverde ◽  
Diego Maria Papurello

2021 ◽  
Vol 12 ◽  
Author(s):  
Ryota Amano ◽  
Setsuro Tsukada ◽  
Shota Kosuge ◽  
Satoshi Yano ◽  
Kenjiro Ono ◽  
...  

Hashimoto's encephalopathy (HE) is an autoimmune encephalopathy that presents with various clinical symptoms, including cognitive deterioration, convulsive seizures, and personality changes. HE is associated with thyroid autoimmunity; however, few cases have been reported to develop as paraneoplastic syndrome. Herein, we report the case of a 73-year-old woman with onset of rapidly progressive dementia. Brain magnetic resonance imaging showed diffuse T2 hyperintensity areas involving the bilateral cerebral white matter, right midbrain tegmental area, left cerebral peduncle, and right middle cerebellar peduncle without clear diffusion hyperintensities and gadolinium enhancement. Her neurological symptoms worsened rapidly, and she presented with the apallic syndrome. Electroencephalogram showed periodic synchronous discharge, suggestive of Creutzfeldt–Jakob disease. However, a brain biopsy revealed infiltration of atypical lymphoid cells expressing CD20, and the anti-NH2 terminal of the α-enolase antibody was detected, diagnosing the complication with lymphomatosis cerebri and HE. High-dose intravenous methylprednisolone therapy and oral prednisolone with whole cranial irradiation enabled her to have simple conversations and consume food orally; however, severe cognitive impairment persisted. Although HE is a rare complication of malignant lymphoma, clinicians should be aware that it could be strongly suspected if the clinical symptoms worsen in the absence of imaging changes.


Sign in / Sign up

Export Citation Format

Share Document