polya signal
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scholarly journals The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus

mBio ◽  
2021 ◽  
Author(s):  
Wolfgang Nacken ◽  
André Schreiber ◽  
Dörthe Masemann ◽  
Stephan Ludwig
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Nonstructural Protein ◽  
Host Gene ◽  
Central Feature ◽  
Effector Domain ◽  
Polya Signal ◽  
Nonstructural Protein 1 ◽  
Host Shutoff

We investigated the role of IAV nonstructural protein 1 NS1 in host gene shutoff—a central feature of IAV replication. We demonstrate that the effector domain of NS1 alone mediates host gene shutoff by inhibition of host transcription and by deregulation of the polyadenylation (polyA) signal-mediated 3′ termination of host transcription.

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