This review is dedicated to the memory of Inesa Kozlovskaya, whose contributions to gravitational physiology was and will continue to be decisive. Dr. Kozlovskaya has developed the concept of gravity-dependent motor control and substantiated the role of supporting afferentation in postural – tonic regulation. It was shown that the support afferentation plays the leading role in the control of the tonic muscle system and regulation of postural synergies. In this review the modern mechanisms of posture-locomotion integration as well as the mechanisms of sensory-motor regulation based on stimulation of foot and muscle receptors in combination with spinal cord stimulation will be considered. Based on the results presented in this review the concept of neurorehabilitation is proposed to be considered as the implementation of various neuromodulations aimed at regulating the functional state of the injured nervous system. The concept is based on the interaction of the processes of regulation of the functional state of the injured brain and sensory input during executing of motor tasks.
