In the last 10 years, we have observed an important increase of interest in the application of time-dependent energy density functional (TD-EDF) theory. This approach allows to treat nuclear structure and nuclear reaction from small to large amplitude dynamics in a unified framework. The possibility to perform unrestricted three-dimensional simulations using state-of-the-art effective interactions has opened new perspectives. In the present paper, an overview of applications where the predictive power of TD-EDF has been benchmarked is given. A special emphasize is made on processes that are of astrophysical interest. Illustrations discussed here include giant resonances, fission, binary and ternary collisions leading to fusion, transfer and deep inelastic processes.