Simple dynamics in non-monotone Kolmogorov systems

In this paper we analyse the global dynamical behaviour of some classical models in the plane. Informally speaking we prove that the folkloric criteria based on the relative positions of the nullclines for Lotka–Volterra systems are also valid in a wide class of discrete systems. The method of proof consists of dividing the plane into suitable positively invariant regions and applying the theory of translation arcs in a subtle manner. Our approach allows us to extend several results of the theory of monotone systems to nonmonotone systems. Applications in models with weak Allee effect, population models for pioneer-climax species, and predator–prey systems are given.

Controlled Lotka-Volterra systems in the modeling of biomedical processes

This book is devoted to a consistent presentation of the recent results obtained by the authors related to controlled systems created based on the Lotka-Volterra competition model, as well as to theoretical and numerical study of the corresponding optimal control problems. These controlled systems describe various modern methods of treating blood cancers, and the optimal control problems stated for such systems, reflect the search for the optimal treatment strategies. The main tool of the theoretical analysis used in this book is the Pontryagin maximum principle - a necessary condition for optimality in optimal control problems. Possible types of the optimal blood cancer treatment - the optimal controls - are obtained as a result of analytical investigations and are confirmed by corresponding numerical calculations. This book can be used as a supplement text in courses of mathematical modeling for upper undergraduate and graduate students. It is our believe that this text will be of interest to all professors teaching such or similar courses as well as for everyone interested in modern optimal control theory and its biomedical applications.

Higher order solitary solutions to the meta-model of diffusively coupled Lotka–Volterra systems

A meta-model of diffusively coupled Lotka–Volterra systems used to model various biomedical phenomena is considered in this paper. Necessary and sufficient conditions for the existence of nth order solitary solutions are derived via a modified inverse balancing technique. It is shown that as the highest possible solitary solution order n is increased, the number of nonzero solution parameter values remains constant for solitary solutions of order $n>3$ n > 3 . Analytical and computational experiments are used to illustrate the obtained results.