Predicting the user navigation pattern from web logs using weighted support approach

<p class="Abstract"><span id="docs-internal-guid-f3d644ee-7fff-d3c1-15b5-f75fe28d3e2d"><span>A weblog contains the history of previous user navigation pattern. If the customer accesses any portal of organization website, the log is generated in web server, based on sequence of user transaction. The weblog stored in the web server as unstructured format, it contains both positive and negative responses i.e. successful and unsuccessful responses, identifying the positive and negative response is not useful for identifying user behavior of individual user. Initially the successful response is taken, from that conversion of unstructured log format to structured log format through data preprocessing technique. The process of data preprocessor contains three step process data cleaning, user identification and session identification. The pattern is discovered by preprocessing technique from that user navigation pattern is generated. From that navigation pattern classifier technique is applied, the conversion of sequence pattern to sub sequence pattern by clustering technique. This research is to identify the user navigation pattern from weblog. The Improved Spanning classification algorithm classifies the frequent, infrequent and semi frequent pattern. To identify the optimal webpage using classificatopn algorithm from thet user behavior is identified.</span></span></p>

A multi-level hypoglycemia early alarm system based on sequence pattern mining

Background Early alarm of hypoglycemia, detection of asymptomatic hypoglycemia, and effective control of blood glucose fluctuation make a great contribution to diabetic treatment. In this study, we designed a multi-level hypoglycemia early alarm system to mine potential information in Continuous Glucose Monitoring (CGM) time series and improve the overall alarm performance for different clinical situations. Methods Through symbolizing the historical CGM records, the Prefix Span was adopted to obtain the early alarm/non-alarm frequent sequence libraries of hypoglycemia events. The longest common subsequence was used to remove the common frequent sequence for achieving the hypoglycemia early alarm in different clinical situations. Then, the frequent sequence pattern libraries with different risk thresholds were designed as the core module of the proposed multi-level hypoglycemia early alarm system. Results The model was able to predict hypoglycemia events in the clinical dataset of level-I (sensitivity 85.90%, false-positive 23.86%, miss alarm rate 14.10%, average early alarm time 20.61 min), level-II (sensitivity 80.36%, false-positive 17.37%, miss alarm rate 19.63%, average early alarm time 27.66 min), and level-III (sensitivity 78.07%, false-positive 13.59%, miss alarm rate 21.93%, average early alarm time 33.80 min), respectively. Conclusions The proposed approach could effectively predict hypoglycemia events based on different risk thresholds to meet different prevention and treatment requirements. Moreover, the experimental results confirm the practicality and prospects of the proposed early alarm system, which reflects further significance in personalized medicine for hypoglycemia prevention.

A computationally designed β-amino acid-containing miniprotein

A new miniprotein built from three helices, including one structure based on a ααβαααβ sequence pattern was developed. Its crystal structure revealed a compact conformation with a well-packed hydrophobic core...

Deep learning for HGT insertion sites recognition

Background Horizontal Gene Transfer (HGT) refers to the sharing of genetic materials between distant species that are not in a parent-offspring relationship. The HGT insertion sites are important to understand the HGT mechanisms. Recent studies in main agents of HGT, such as transposon and plasmid, demonstrate that insertion sites usually hold specific sequence features. This motivates us to find a method to infer HGT insertion sites according to sequence features. Results In this paper, we propose a deep residual network, DeepHGT, to recognize HGT insertion sites. To train DeepHGT, we extracted about 1.55 million sequence segments as training instances from 262 metagenomic samples, where the ratio between positive instances and negative instances is about 1:1. These segments are randomly partitioned into three subsets: 80% of them as the training set, 10% as the validation set, and the remaining 10% as the test set. The training loss of DeepHGT is 0.4163 and the validation loss is 0.423. On the test set, DeepHGT has achieved the area under curve (AUC) value of 0.8782. Furthermore, in order to further evaluate the generalization of DeepHGT, we constructed an independent test set containing 689,312 sequence segments from another 147 gut metagenomic samples. DeepHGT has achieved the AUC value of 0.8428, which approaches the previous test AUC value. As a comparison, the gradient boosting classifier model implemented in PyFeat achieve an AUC value of 0.694 and 0.686 on the above two test sets, respectively. Furthermore, DeepHGT could learn discriminant sequence features; for example, DeepHGT has learned a sequence pattern of palindromic subsequences as a significantly (P-value=0.0182) local feature. Hence, DeepHGT is a reliable model to recognize the HGT insertion site. Conclusion DeepHGT is the first deep learning model that can accurately recognize HGT insertion sites on genomes according to the sequence pattern.