Impact Of The Ferrocenyl Group On Cytotoxicity And KSP Inhibitory Activity Of Ferrocenyl Monastrol Conjugates

The incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl analogs of monastrol –...

5-Chloro-2-ferrocenylbenzo[d]oxazole

The asymmetric unit of the title compound, [Fe(C5H5)(C12H7ClNO)], consists of one ferrocenyl group bonded to chlorobenzo[d]oxazole. The conformation of the ferrocenyl moiety is slightly away from eclipsed. The bond angles between the 5-chloro-benzoxazole and ferrocenyl fragments are N—C—C = 127.4 (7)° and O—C—C = 116.8 (7)°. The benzo[d]oxazole ring is planar (r.m.s. deviation = 0.0042 Å) and makes an angle of 11.3 (4)° with the cyclopentadienyl ring attached to it. The crystal packing is characterized by intermolecular π–π contacts, resulting in chain formation along the b-axis direction. The centroid-to-centroid distance between the six- and five-membered rings is 3.650 (5) Å. Together with a C—H...π interaction, these intermolecular contacts form laminar arrays along the ac plane.

Electrofugality of Some Ferrocenylphenylmethyl Cations

The electrofugality scale has been extended with new substituted ferrocenylphenylmethyl cations 1-4. Ef values were determined by applying the linear free energy relationship (LFER): log k = sf (Ef + Nf). Due to ability of the ferrocene moiety to efficiently stabilize the positive charge, ferrocenylphenylmethyl cations constitute a group of very powerful electrofuges (Ef > 1). Impact of the phenyl group in ferrocenylphenylmethyl derivatives on stabilization of the positive charge is considerably leveled by the ferrocenyl group, so the rate effect of the alkyl substituents (methyl, ethyl and tert-butyl) on the phenyl ring is suppressed, causing narrow range of Ef parameters. Lack of breakdown of Hammett-Brown plot if the rates for the complete set of substrates 1–5 have been correlated, indicates that the ferrocenyl group in α-position diminishes the stabilizing effects of electron-donating substituents as well.

(Ar–CO–CC)(PEt3)Au and (Ar–CC)(PEt3)Au complexes bearing pyrenyl and ferrocenyl groups: synthesis, structure, and luminescence properties

ArCOCCAuPEt3(1aand1b) and ArCCCAuPEt3(2aand2b) bearing Ar = pyren-1-yl or ferrocenyl group were synthesized and the structure, ligand scrambling in solution and luminescence properties were investigated.

Crystal Structure of a Heterometallic Luminophore: The RuII Complex of a Ferrocenyl-Terpyridine with a Flexible Linkage

Crystal structure determination on the mixed ligand complex [Ru(tpy)(L1)](ClO4)2 (tpy = 2,2′:6′,2″-terpyridine; L1 = 4′-(ferrocenylmethylaminomethylphenyl)terpyridine) shows the ferrocenyl group to be located as remotely as possible from the RuII centre. This may explain the fact that emission from the RuII centre is detectable even at room temperature in solution.