Oxidative [3+2]-annulation of nitroalkenes and azolium ylides in the presence of Cu(II): efficient synthesis of [5,5]-annulated N-fused heterocycles

A facile synthesis of [5,5]-annulated N-fused heterocycles – pyrrolo[2,1-b]thiazoles and pyrrolo[1,2-b]indazoles via Cu(II)-mediated oxidative [3+2]-annulation between nitroalkenes and azolium ylides was developed. The reaction proceeds in mild conditions with copper (II) trifluoroacetate/2,6-lutidine system as a promoter. The method is applicable to a broad range of nitroalkenes and azolium salts, providing target N-fused heterocycles in moderate to good yields. In the case of α-fluoronitroalkenes unique fluorinated derivatives were accessed via this methodology.

Structural and spectral properties of a non-classical C58 isomer and its fluorinated derivatives in theory

The X-ray spectra have good isomer dependence and give a comprehensive insight of the electronic structure of the system.

Introducing Deep Eutectic Solvents in Enolate Chemistry: Synthesis of 1-Arylpropan-2-ones under Aerobic Conditions

Alkoxide-mediated enolization of 1-arylpropan-2-ones and their fluorinated derivatives, followed by α-functionalization with nucleophilic addition and substitution reactions, has been accomplished in the enviromentally friendly eutectic mixture choline chloride/urea, under aerobic...