The objective of this study was to investigate the diagnosis of colonic polyps (CP) through the computed tomography (CT) images combined with colonoscopy based on Fourier central slice theorem algorithm. In this study, 86 patients with CP admitted to hospital were selected as research objects. CT imaging and colonoscopy were applied to diagnose the patients based on the algorithm of Fourier central slice theorem. The results showed that the diagnostic detection rates of CP and colon cancer (CC) were 88.2% and 94.2%, respectively. The occurrence site of CP was the sigmoid and ascending colon. 38 patients were positive for serosal invasion of CP while 42 patients were negative for serosal invasion of CP, and there were no statistical differences (
P
>
0.05
). The lesion positions of remaining 6 cases were hard to find and could not be detected accurately. Besides, the diagnostic accuracy of preoperative and postoperative stages III and IV was all 100.00%. The combination of CT imaging and colonoscopy was employed to diagnose CP, which was found to be able to accurately locate the lesions, to effectively evaluate the tumor stage before and after surgery, and to have a good diagnostic efficacy in detecting tumor serosal layer.