mrnp complex
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2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Helisa Helena Wippel ◽  
Juliane Soldi Malgarin ◽  
Alexandre Haruo Inoue ◽  
Felipe da Veiga Leprevost ◽  
Paulo Costa Carvalho ◽  
...  


RNA Biology ◽  
2018 ◽  
pp. 1-13 ◽  
Author(s):  
Helisa Helena Wippel ◽  
Alexandre Haruo Inoue ◽  
Newton Medeiros Vidal ◽  
Jimena Ferreira da Costa ◽  
Bruna Hilzendeger Marcon ◽  
...  


2011 ◽  
Vol 124 (24) ◽  
pp. 4299-4308 ◽  
Author(s):  
Laura R. Serbus ◽  
Amy Ferreccio ◽  
Mariya Zhukova ◽  
Chanel L. McMorris ◽  
Elena Kiseleva ◽  
...  
Keyword(s):  


2011 ◽  
Vol 41 (4) ◽  
pp. 419-431 ◽  
Author(s):  
George S. Hussey ◽  
Arindam Chaudhury ◽  
Andrea E. Dawson ◽  
Daniel J. Lindner ◽  
Charlotte R. Knudsen ◽  
...  
Keyword(s):  


2006 ◽  
Vol 10 (5) ◽  
pp. 601-613 ◽  
Author(s):  
Ming-Der Lin ◽  
Shih-Jung Fan ◽  
Wei-Shan Hsu ◽  
Tze-Bin Chou
Keyword(s):  


2001 ◽  
Vol 21 (17) ◽  
pp. 5879-5888 ◽  
Author(s):  
Jia Yu ◽  
J. Eric Russell

ABSTRACT Human globins are encoded by mRNAs exhibiting high stabilities in transcriptionally silenced erythrocyte progenitors. Unlike α-globin mRNA, whose stability is enhanced by assembly of a specific messenger RNP (mRNP) α complex on its 3′ untranslated region (UTR), neither the structure(s) nor the mechanism(s) that effects the high-level stability of human β-globin mRNA has been identified. The present work describes an mRNP complex assembling on the 3′ UTR of the β-globin mRNA that exhibits many of the properties of the stability-enhancing α complex. The β-globin mRNP complex is shown to contain one or more factors homologous to αCP, a 39-kDa RNA-binding protein that is integral to α-complex assembly. Sequence analysis implicates a specific 14-nucleotide pyrimidine-rich track within its 3′ UTR as the site of β-globin mRNP assembly. The importance of this track to mRNA stability is subsequently verified in vivo using mice expressing human β-globin transgenes that contain informative mutations in this region. In combination, the in vitro and in vivo analyses indicate that the high stabilities of the α- and β-globin mRNAs are maintained through related mRNP complexes that may share a common regulatory pathway.



Neuron ◽  
2001 ◽  
Vol 31 (2) ◽  
pp. 261-275 ◽  
Author(s):  
H.L. Zhang ◽  
T. Eom ◽  
Y. Oleynikov ◽  
S.M. Shenoy ◽  
D.A. Liebelt ◽  
...  
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