large cell lung carcinoma
Recently Published Documents


TOTAL DOCUMENTS

46
(FIVE YEARS 1)

H-INDEX

7
(FIVE YEARS 0)

2021 ◽  
Vol 11 ◽  
Author(s):  
Guihua Wang ◽  
Qin Chai ◽  
Yajie Xiao ◽  
Wenying Peng ◽  
Miao Teng ◽  
...  

Immune checkpoint inhibitors have revolutionized the treatments of lung cancers, and multiple predictive biomarkers alone or in combination help clinicians with the appropriate therapeutic selections. Recently, chemo-immunotherapy has been recommended for treating advanced non-small cell lung cancers in patients without driver mutations. However, the clinical relevance of predictive biomarkers and the treatment efficacy of chemo-immunotherapy in large cell lung carcinoma (LCLC) remain unclear. Here, we reported a rare case of LCLC with none driver gene mutations and low values of multiple predictive biomarkers. These biomarkers included a low PD-L1 expression of 5–10%, a low tumor mutational burden (TMB) of 2.5 muts/mb, a low CD8(+) tumor-infiltrating lymphocyte density of 147.91 psc/mm². After one-cycle chemotherapy, the patient progressed rapidly and then was switched to pembrolizumab combining paclitaxel plus cisplatin. Interestingly, he achieved a partial response after two cycles of chemo-immunotherapy, showing multiple lymph nodes obviously shrunk on CT scan, and other clinical symptoms were relieved when compared with the baseline findings. After five cycles of chemo-immunotherapy, this advanced patient still benefited and was changed to maintenance immunotherapy monotherapy. This case suggests that chemo-immunotherapy may provide an effective therapeutic option for those LCLC patients with low values of multiple predictive biomarkers, particularly for those who progressed from first-line classical treatments.



2020 ◽  
Vol 31 ◽  
pp. 101197
Author(s):  
Ryunosuke Ooi ◽  
Kazunori Tobino ◽  
Mitsukuni Sakabe ◽  
Takafumi Kawabata ◽  
Yuri Hiramatsu ◽  
...  


2019 ◽  
Vol 58 (22) ◽  
pp. 3289-3294 ◽  
Author(s):  
Kyoko Yagyu ◽  
Takahiro Ueda ◽  
Atsushi Miyamoto ◽  
Riki Uenishi ◽  
Haruhiko Matsushita ◽  
...  


2019 ◽  
Vol 51 (10) ◽  
pp. 1082-1085
Author(s):  
Yifeng Gong ◽  
Xue Li ◽  
Lei Deng ◽  
Li Jin ◽  
Youxin Jin ◽  
...  


2019 ◽  
Vol 15 (4) ◽  
pp. 1010-1016
Author(s):  
Barbara Brominska ◽  
Piotr Gabryel ◽  
Donata Jarmołowska-Jurczyszyn ◽  
Małgorzata Janicka-Jedyńska ◽  
Andrzej Kluk ◽  
...  


2019 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Funda Incekara ◽  
Gokturk Findik ◽  
Ebru Guven Sayilir ◽  
Koray Aydogdu ◽  
Mustafa Sevki Demiroz ◽  
...  


2018 ◽  
Vol 13 (9) ◽  
pp. e165-e168 ◽  
Author(s):  
Yi-Jun Xu ◽  
Zhen -Liang Shi ◽  
Zheng Wang ◽  
Lin Du ◽  
Shi-Zhao Cheng ◽  
...  


Sign in / Sign up

Export Citation Format

Share Document