This chapter begins by looking at retinal anatomy and physiology, before covering key clinical and practical skills, namely posterior segment history taking and examination, diagnostic lenses, optical coherence tomography, ultrasonography, and retinal photocoagulation. The following areas of clinical knowledge are then discussed: vitreous disorders, retinal detachment, peripheral retinal abnormalities, macular surgery, submacular surgery, retinal tumours, choroidal tumours, vitreoretinopathies, retinopathy of prematurity, and posterior segment trauma. The chapter concludes with two case-based discussions, on retinal detachment and elevated fundal mass.